INT193554

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.73
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ntrk2, Ephb1) plasma membrane (Ntrk2, Ephb1) cytosol (Ntrk2)
signal transduction (Ephb1) aging (Ntrk2) cytoplasm (Ephb1)
Anatomy Link Frequency
nerve 2
Ntrk2 (Rattus norvegicus)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 30 97.72 Very High Very High Very High
Nerve growth factor 10 96.72 Very High Very High Very High
cytokine 4 96.28 Very High Very High Very High
allodynia 4 85.40 High High
Neuropathic pain 2 52.24 Quite High
halothane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nervous System Injury 14 100.00 Very High Very High Very High
Neuropathic Pain 6 85.40 High High
Injury 14 83.48 Quite High
Apoptosis 2 65.64 Quite High
Death 2 44.32 Quite Low
Ganglion Cysts 2 43.32 Quite Low
Wallerian Degeneration 4 5.00 Very Low Very Low Very Low
Mycobacterium Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence suggests that this increased activity of ERK is mediated by endogenous neurotrophic factors known to stimulate axonal regeneration.
factors Positive_regulation (mediated) of Positive_regulation (increased) of ERK
1) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.40 Pain Relevance 0.38
Some evidence shows that the upregulated growth factors after nerve injury may be responsible for this ERK activation in DRG.
factors Positive_regulation (responsible) of Positive_regulation (activation) of ERK in nerve associated with nervous system injury
2) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501035 Disease Relevance 0.32 Pain Relevance 0.14

General Comments

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