INT193558

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.50
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nr1i3) cytoskeleton (Nr1i3) nucleus (Nr1i3)
DNA binding (Nr1i3) cytoplasm (Nr1i3)
Anatomy Link Frequency
CAR 1
Nr1i3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 17 93.72 High High
Nucleus accumbens 43 90.48 High High
addiction 2 90.08 High High
agonist 7 88.00 High High
antagonist 18 62.00 Quite High
Glutamate receptor 2 50.00 Quite Low
Bile 5 49.44 Quite Low
cocaine 7 42.48 Quite Low
Eae 6 7.80 Low Low
depression 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 5 88.40 High High
Hepatotoxicity 25 57.36 Quite High
Apoptosis 6 57.00 Quite High
Death 4 56.60 Quite High
Toxicity 28 48.64 Quite Low
Injury 2 29.52 Quite Low
Pathologic Processes 1 27.80 Quite Low
Biliary Cancer 2 12.32 Low Low
Stress 26 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coupled with the down-regulation of PXR, methapyrilene also induced a liver-dependent down-regulation of the constitutive androstane receptor (CAR/Nr1i3; GenBank accession no.
Negative_regulation (regulation) of androstane receptor in CAR
1) Confidence 0.03 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852695 Disease Relevance 0.50 Pain Relevance 0
Group I blockade impaired corticostriatal synaptic plasticity [41].
Negative_regulation (blockade) of Group I
2) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1501036 Disease Relevance 0 Pain Relevance 0.34

General Comments

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