INT193582

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 21
Total Number 24
Disease Relevance 14.00
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PVR) extracellular region (PVR) nucleolus (PVR)
plasma membrane (PVR) nucleus (PVR) cytoplasm (PVR)
Anatomy Link Frequency
monocyte 2
pulmonary artery 2
macrophages 1
leukocytes 1
fat pads 1
PVR (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 102 97.72 Very High Very High Very High
medulla 16 96.28 Very High Very High Very High
Inflammation 137 95.24 Very High Very High Very High
Spinal cord 36 92.28 High High
cva 14 89.48 High High
Pain 60 85.04 High High
ischemia 21 84.72 Quite High
Sciatic nerve 6 83.16 Quite High
Thalamus 28 81.12 Quite High
iatrogenic 6 71.36 Quite High
Disease Link Frequency Relevance Heat
Persistent Vegetative State 620 100.00 Very High Very High Very High
Disease 98 100.00 Very High Very High Very High
Syndrome 36 100.00 Very High Very High Very High
Nociception 6 100.00 Very High Very High Very High
Cv Unclassified Under Development 32 99.68 Very High Very High Very High
Polio 336 99.56 Very High Very High Very High
Paralysis 60 99.24 Very High Very High Very High
Infection 96 98.72 Very High Very High Very High
Eisenmenger Complex 3 98.46 Very High Very High Very High
Arrhythmias 2 Under Development 124 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, the PVS Task-Force [7], recognized that in PVS patients "subcortical nociceptive responses produce patterned behaviors, such as grimace-like or crying-like behavior similar to that accompanying conscious emotional responses."
Gene_expression (produce) of PVS associated with nociception and persistent vegetative state
1) Confidence 0.58 Published 2007 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2245970 Disease Relevance 1.34 Pain Relevance 0.49
All the basic mechanisms of thirst exist in brain areas that typically remain undamaged in PVS.
Gene_expression (undamaged) of PVS in brain associated with persistent vegetative state
2) Confidence 0.58 Published 2007 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2245970 Disease Relevance 0.44 Pain Relevance 0
Neuroimaging of PVS
Gene_expression (Neuroimaging) of PVS associated with persistent vegetative state
3) Confidence 0.58 Published 2007 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2245970 Disease Relevance 1.44 Pain Relevance 0.30
Possible conscious awareness in PVS
Gene_expression (awareness) of PVS associated with persistent vegetative state
4) Confidence 0.58 Published 2007 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2245970 Disease Relevance 0.63 Pain Relevance 0
In the exploratory data analysis, PVR in general was low at baseline, ranging from 0 to 99 mL (PVR >100 mL was an exclusion criterion in the clinical trials); at last visit, PVR ranged from 0 to 404 mL.
Gene_expression (exclusion) of PVR
5) Confidence 0.54 Published 2010 Journal BMC Urol Section Body Doc Link PMC2939595 Disease Relevance 0.11 Pain Relevance 0
The longitudinal profile of PVR did not show any relevant pattern, even in subjects who reached PVR >100 mL at some point during treatment.
Gene_expression (profile) of PVR
6) Confidence 0.54 Published 2010 Journal BMC Urol Section Body Doc Link PMC2939595 Disease Relevance 0.28 Pain Relevance 0
A dose-dependent increase in PVR >100 mL was apparent in men and patients aged >70 years but not in women or patients aged ?
Gene_expression (>100) of PVR
7) Confidence 0.54 Published 2010 Journal BMC Urol Section Body Doc Link PMC2939595 Disease Relevance 0.28 Pain Relevance 0
In the exploratory data analysis, PVR in general was low at baseline, ranging from 0 to 99 mL (PVR >100 mL was an exclusion criterion in the clinical trials); at last visit, PVR ranged from 0 to 404 mL.
Gene_expression (exclusion) of PVR
8) Confidence 0.54 Published 2010 Journal BMC Urol Section Body Doc Link PMC2939595 Disease Relevance 0.06 Pain Relevance 0
Following this line of thought, evidence for entry of PV into the CNS via infected macrophages is largely circumstantial, emerging from observations that PV replicates in macrophages expressing CD155 [51,57] and that macrophages infected with Visna virus [151] and human immunodeficiency virus (HIV) [54] traverse the BBB.
Gene_expression (expressing) of CD155 in macrophages associated with visna, acquired immune deficiency syndrome or hiv infection and central nervous system
9) Confidence 0.52 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.61 Pain Relevance 0.37
The biochemical synthesis of poliovirus
Gene_expression (synthesis) of poliovirus
10) Confidence 0.52 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.41 Pain Relevance 0
The term persistent vegetative state (PVS) is applied when the clinical criteria of vegetative state persist for at least 1 month after the patient has suffered impaired consciousness.
Gene_expression (applied) of PVS associated with persistent vegetative state
11) Confidence 0.47 Published 2009 Journal Med Health Care Philos Section Body Doc Link PMC2777223 Disease Relevance 1.30 Pain Relevance 0
Functional neuroimaging methods have demonstrated that aspects of speech perception, emotional processing, language comprehension, and even conscious awareness might be retained in some patients who behaviorally meet all of the criteria that define PVS (Owen and Coleman 2008).
Gene_expression (define) of PVS associated with persistent vegetative state
12) Confidence 0.47 Published 2009 Journal Med Health Care Philos Section Body Doc Link PMC2777223 Disease Relevance 0.83 Pain Relevance 0.03
The four categories into which human enteroviruses were subdivided were: (1) polioviruses, which caused flaccid paralysis (poliomyelitis) in humans but not in suckling mice lacking CD155; (2) coxsackie A viruses (CAV), which were linked to human central nervous system (CNS) pathology and skeletal muscle inflammation (myositis) as well as acute flaccid paralysis in suckling mice; (3) coxsackie B viruses (CBV), associated with ailments of the human cardiac and central nervous systems, and necrosis of the fat pads between the shoulders, focal lesions in skeletal muscle, brain, and spinal cord, as well as spastic paralysis in the suckling mouse experimental model; and (4) echoviruses, which were not originally associated with human disease nor with paralysis in mice [41,121,201].
Neg (lacking) Gene_expression (suckling) of CD155 in fat pads associated with polio, cerebral palsy, disease, myositis, spinal cord, necrosis, inflammation, central nervous system and paralysis
13) Confidence 0.45 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 1.18 Pain Relevance 0.19
The poliovirus 5' Non-Translated Region (5'NTR)
Gene_expression (The) of poliovirus
14) Confidence 0.45 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.10 Pain Relevance 0
Poliovirus vaccines
Gene_expression (vaccines) of Poliovirus
15) Confidence 0.45 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.62 Pain Relevance 0.26
The Enterovirus genus, to which the polioviruses belong, can be further subdivided into eight clusters (i.e., Poliovirus, Human enterovirus A, Human enterovirus B, Human enterovirus C, Human enterovirus D, Simian enterovirus A, Bovine enterovirus, and Porcine enterovirus B) (Table 2), which include predominantly human pathogens exhibiting marked variation in the disease syndromes they produce.
Gene_expression (produce) of Poliovirus associated with syndrome and disease
16) Confidence 0.40 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.84 Pain Relevance 0.09
They found that the superior PVs were significantly dilated and were the commonest source of the ectopic beats initiating paroxysmal AF.
Gene_expression (source) of PVs in superior associated with cv unclassified under development and arrhythmias 2 under development
17) Confidence 0.36 Published 2004 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC1501062 Disease Relevance 0.59 Pain Relevance 0.04
Eight patients on stable doses of epoprostenol (average 100 ng/kg/min) had continuous hemodynamic monitoring for 2 days during initiation with 62.5 mg bosentan twice daily.35 Even while reducing epoprostenol to maintain SvO2 at baseline value, systolic pulmonary artery pressure and PVR fell; these changes were maintained in six of the patients at 1 year.35
Gene_expression (fell) of PVR in pulmonary artery
18) Confidence 0.31 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2725793 Disease Relevance 0.40 Pain Relevance 0
Sixteen weeks of bosentan therapy improved 6MWD to 424 m from 333 m at baseline, with hemodynamic improvement and 13 patients attaining FC II status.12 A placebo-controlled study (BREATHE-5) looked at the effects of bosentan in 52 subjects with Eisenmenger syndrome with an added safety endpoint of systemic oxygen saturation. 6MWD, mPAP and PVR were significantly improved with only a 1% drop in oxygen saturations.14 Data from the open-label extension reported an overall improvement in 6MWD at 24 weeks with a drop of only 0.5% in systemic arterial saturations.40 A multi-center trial of bosentan in patients with inoperable chronic thromboembolic pulmonary hypertension showed hemodynamic improvement but not benefit in exercise capacity.15
Gene_expression (improved) of PVR associated with pulmonary hypertension, eisenmenger complex and cva
19) Confidence 0.31 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2725793 Disease Relevance 0.97 Pain Relevance 0.04
Eight patients on stable doses of epoprostenol (average 100 ng/kg/min) had continuous hemodynamic monitoring for 2 days during initiation with 62.5 mg bosentan twice daily.35 Even while reducing epoprostenol to maintain SvO2 at baseline value, systolic pulmonary artery pressure and PVR fell; these changes were maintained in six of the patients at 1 year.35
Gene_expression (pressure) of PVR in pulmonary artery
20) Confidence 0.31 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2725793 Disease Relevance 0.40 Pain Relevance 0

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