INT19359

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Context Info
Confidence 0.47
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.63
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (BRCA2) chromosome organization (BRCA2) nucleolus (BRCA2)
nucleus (BRCA2) cell cycle (BRCA2) DNA binding (BRCA2)
BRCA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 1 95.60 Very High Very High Very High
melanocortin 1 receptor 1 93.96 High High
imagery 20 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Hsan 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 41 99.52 Very High Very High Very High
Breast Cancer 368 99.08 Very High Very High Very High
Cutaneous Melanoma 1 92.64 High High
Disease 79 83.84 Quite High
Sprains And Strains 3 81.44 Quite High
Cancer 175 80.36 Quite High
Sunburn 8 80.36 Quite High
Metastasis 23 59.52 Quite High
Fanconi Anemia 4 59.16 Quite High
Recurrence 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The NDH-2 enzymes are generally single polypeptides and contain noncovalently bound FAD and no iron-sulfur clusters.
FAD Binding (bound) of
1) Confidence 0.47 Published 1991 Journal J. Bioenerg. Biomembr. Section Abstract Doc Link 2050655 Disease Relevance 0.08 Pain Relevance 0.10
Overall alterations of FANCC showed significant association with deletion of BRCA2 in both group-A (P = 0.03) and group-B (P = 0.02).
BRCA2 Binding (association) of
2) Confidence 0.47 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.44 Pain Relevance 0
We also need to find other proteins that interact with BRCA1 and BRCA2 and elucidate the post-translational modifications that occur as a result of these interactions.
BRCA2 Binding (interact) of
3) Confidence 0.44 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397525 Disease Relevance 0.75 Pain Relevance 0
A significant association between BRCA2 and excess melanoma has also been reported [17].
BRCA2 Binding (association) of associated with melanoma
4) Confidence 0.35 Published 2006 Journal Int J Health Geogr Section Body Doc Link PMC1557666 Disease Relevance 0.66 Pain Relevance 0.09
Further analysis has shown that allelic variation at FGFR2, TNRC9, 8q24, 2q35, and 5p12 is associated with physiological characteristics of breast tumors, such as ER status [62, 64, 65], and specific FGFR2, MAP3K1, and TNRC9 variants may interact with BRCA1 and BRCA2 mutations to increase breast cancer risk [66].
BRCA2 Binding (interact) of associated with breast cancer
5) Confidence 0.26 Published 2010 Journal Current Genomics Section Body Doc Link PMC2878980 Disease Relevance 0.70 Pain Relevance 0

General Comments

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