INT19359

Context Info Confidence 0.47 First Reported 1991 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 2.63 Pain Relevance 0.19

nucleoplasm (BRCA2) chromosome organization (BRCA2) nucleolus (BRCA2) nucleus (BRCA2) cell cycle (BRCA2) DNA binding (BRCA2)

BRCA2 (Homo sapiens)

Pain Link Frequency Relevance Heat qutenza 1 95.60 melanocortin 1 receptor 1 93.96 imagery 20 5.00 palliative 3 5.00 Inflammation 2 5.00 Hsan 1 5.00 COX-2 inhibitor 1 5.00 Pain 1 5.00 alcohol 1 5.00 metalloproteinase 1 5.00

Disease Link Frequency Relevance Heat Melanoma 41 99.52 Breast Cancer 368 99.08 Cutaneous Melanoma 1 92.64 Disease 79 83.84 Sprains And Strains 3 81.44 Cancer 175 80.36 Sunburn 8 80.36 Metastasis 23 59.52 Fanconi Anemia 4 59.16 Recurrence 28 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The NDH-2 enzymes are generally single polypeptides and contain noncovalently bound FAD and no iron-sulfur clusters.

FAD Binding (bound) of

1) Confidence 0.47 Published 1991 Journal J. Bioenerg. Biomembr. Section Abstract Doc Link 2050655 Disease Relevance 0.08 Pain Relevance 0.10

Overall alterations of FANCC showed significant association with deletion of BRCA2 in both group-A (P = 0.03) and group-B (P = 0.02).

BRCA2 Binding (association) of

2) Confidence 0.47 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2633285 Disease Relevance 0.44 Pain Relevance 0

We also need to find other proteins that interact with BRCA1 and BRCA2 and elucidate the post-translational modifications that occur as a result of these interactions.

BRCA2 Binding (interact) of

3) Confidence 0.44 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397525 Disease Relevance 0.75 Pain Relevance 0

A significant association between BRCA2 and excess melanoma has also been reported [17].

BRCA2 Binding (association) of associated with melanoma

4) Confidence 0.35 Published 2006 Journal Int J Health Geogr Section Body Doc Link PMC1557666 Disease Relevance 0.66 Pain Relevance 0.09

Further analysis has shown that allelic variation at FGFR2, TNRC9, 8q24, 2q35, and 5p12 is associated with physiological characteristics of breast tumors, such as ER status [62, 64, 65], and specific FGFR2, MAP3K1, and TNRC9 variants may interact with BRCA1 and BRCA2 mutations to increase breast cancer risk [66].

BRCA2 Binding (interact) of associated with breast cancer

5) Confidence 0.26 Published 2010 Journal Current Genomics Section Body Doc Link PMC2878980 Disease Relevance 0.70 Pain Relevance 0

General Comments

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