INT193602

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.80
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (HTT) endoplasmic reticulum (HTT) protein complex (HTT)
cytoplasm (HTT) cytosol (HTT) cell death (HTT)
Anatomy Link Frequency
skin 2
reservoir 1
HTT (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 22 32.32 Quite Low
imagery 36 5.00 Very Low Very Low Very Low
Inflammation 24 5.00 Very Low Very Low Very Low
anesthesia 14 5.00 Very Low Very Low Very Low
cINOD 12 5.00 Very Low Very Low Very Low
cva 8 5.00 Very Low Very Low Very Low
isoflurane 8 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Clonidine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 868 100.00 Very High Very High Very High
Toxicity 30 99.60 Very High Very High Very High
Targeted Disruption 4 98.60 Very High Very High Very High
Emergencies 14 79.48 Quite High
Wound Healing 82 76.80 Quite High
Foreign Bodies 4 70.12 Quite High
Blister 138 69.76 Quite High
Disease 26 53.48 Quite High
Neurodegenerative Disease 11 50.00 Quite Low
Frontotemporal Dementia 2 43.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We showed that rapamycin attenuated mutant huntingtin fragment toxicity in cells and in transgenic Drosophila and mouse models of HD (37).
Negative_regulation (attenuated) of huntingtin associated with targeted disruption and toxicity
1) Confidence 0.41 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2856980 Disease Relevance 0.25 Pain Relevance 0
In this study, no significant reduction of HD was detected over the operating field.
Neg (no) Negative_regulation (reduction) of HD
2) Confidence 0.11 Published 2008 Journal Eplasty Section Body Doc Link PMC2481389 Disease Relevance 0.09 Pain Relevance 0
In this study, a significant amount of HD was extracted from the wound swabs taken immediately before surgery (60% of the applied dose, on average).
Negative_regulation (amount) of HD associated with injury
3) Confidence 0.09 Published 2008 Journal Eplasty Section Body Doc Link PMC2481389 Disease Relevance 0.64 Pain Relevance 0
Because of the low volatility of HD and the limited surface area on which the applied HD was exposed to air, the amount of applied HD lost to evaporation was likely very small.
Negative_regulation (lost) of HD
4) Confidence 0.08 Published 2008 Journal Eplasty Section Body Doc Link PMC2481389 Disease Relevance 0.26 Pain Relevance 0
The existence of a dermal reservoir of HD in humans was first suggested in World War I by Smith et al,47 who demonstrated that HD injuries could be prevented by washing contaminated skin with an appropriate solvent up to 45 minutes postexposure.
Negative_regulation (prevented) of HD in reservoir associated with injury
5) Confidence 0.08 Published 2008 Journal Eplasty Section Body Doc Link PMC2481389 Disease Relevance 0.27 Pain Relevance 0
Understanding the kinetics of HD skin absorption, and the amount and persistence of unbound HD in putative agent reservoirs, will aid in choosing the most appropriate decontaminating agent and in determining its application doctrine and its window of effective use.
Negative_regulation (persistence) of HD in skin
6) Confidence 0.05 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0.13 Pain Relevance 0
Any decontaminating agent that is capable of pulling the targeted agent out of the skin as well as neutralizing it on the surface of the skin has the potential to decrease HD-induced pathology, even beyond the 2-min efficacy window15 of conventional decontamination procedures.
Negative_regulation (decrease) of HD in skin
7) Confidence 0.05 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0.15 Pain Relevance 0

General Comments

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