INT193603

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Context Info
Confidence 0.16
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 2.74
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (HTT) endoplasmic reticulum (HTT) protein complex (HTT)
cytoplasm (HTT) cytosol (HTT) cell death (HTT)
Anatomy Link Frequency
skin 7
reservoir 4
motoneuron 1
HTT (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 78 80.56 Quite High
Inflammation 86 59.44 Quite High
Central nervous system 27 48.88 Quite Low
corticosteroid 14 23.80 Low Low
Potency 7 13.04 Low Low
imagery 126 5.00 Very Low Very Low Very Low
cINOD 42 5.00 Very Low Very Low Very Low
anesthesia 22 5.00 Very Low Very Low Very Low
cva 19 5.00 Very Low Very Low Very Low
cytokine 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 2048 97.00 Very High Very High Very High
Emergencies 22 88.72 High High
Wound Healing 269 87.40 High High
Foreign Bodies 5 81.36 Quite High
Blister 465 79.12 Quite High
Disease 23 60.68 Quite High
INFLAMMATION 121 59.44 Quite High
Erythema 84 55.40 Quite High
Aging 85 50.00 Quite Low
Body Weight 21 42.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, studies conducted during World War II reported the opposite effect in that HD was rapidly “fixed” by skin constituents such as proteins (Renshaw48).
Localization (fixed) of HD in skin
1) Confidence 0.16 Published 2008 Journal Eplasty Section Body Doc Link PMC2481389 Disease Relevance 0.22 Pain Relevance 0
Furthermore, Smith et al demonstrated that the skin reservoir of HD could be transferred to a second individual, even after the exposed surface had been decontaminated.
Localization (reservoir) of HD in reservoir
2) Confidence 0.15 Published 2008 Journal Eplasty Section Body Doc Link PMC2481389 Disease Relevance 0.25 Pain Relevance 0
The existence of a dermal reservoir of HD in humans was first suggested in World War I by Smith et al,47 who demonstrated that HD injuries could be prevented by washing contaminated skin with an appropriate solvent up to 45 minutes postexposure.
Localization (reservoir) of HD in reservoir associated with injury
3) Confidence 0.13 Published 2008 Journal Eplasty Section Body Doc Link PMC2481389 Disease Relevance 0.27 Pain Relevance 0
Contemporary in vitro studies have confirmed the original work of Smith et al that a substantial reservoir of HD is formed in human skin that can account for up to 35% of the applied dose after 24 hours.49 Work is under way to further examine the toxicology of this reservoir in both pig and human skin exposed to radiolabeled HD ex vivo.
Localization (reservoir) of HD in reservoir
4) Confidence 0.13 Published 2008 Journal Eplasty Section Body Doc Link PMC2481389 Disease Relevance 0.20 Pain Relevance 0
Ex vivo studies to examine the existence, kinetics, and time course of a reservoir of unreacted HD in pig and human skin are nearing completion and results will be reported soon.
Localization (reservoir) of HD in skin
5) Confidence 0.13 Published 2008 Journal Eplasty Section Body Doc Link PMC2481389 Disease Relevance 0.75 Pain Relevance 0
Furthermore, Smith et al demonstrated that the skin reservoir of HD could be transferred to a second individual, even after the exposed surface had been decontaminated.
Localization (reservoir) of HD in skin
6) Confidence 0.08 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0.16 Pain Relevance 0
The best agent will be the one that not only decontaminates HD sitting on the surface of the skin, but also is capable of fully penetrating the stratum corneum and neutralizing any unbound agent reservoir located there, unlike previous reactive therapies.68 Research is underway to develop an in vitro model for efficacy testing of advanced decontaminating agents capable of pulling HD out of the skin reservoir and neutralizing HD on the surface of the skin, to identify the most appropriate animal model for extrapolation of animal data to humans, and to conduct in vivo efficacy tests of candidate decontamination systems.


Localization (neutralizing) of HD in skin
7) Confidence 0.07 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0 Pain Relevance 0.08
The best agent will be the one that not only decontaminates HD sitting on the surface of the skin, but also is capable of fully penetrating the stratum corneum and neutralizing any unbound agent reservoir located there, unlike previous reactive therapies.68 Research is underway to develop an in vitro model for efficacy testing of advanced decontaminating agents capable of pulling HD out of the skin reservoir and neutralizing HD on the surface of the skin, to identify the most appropriate animal model for extrapolation of animal data to humans, and to conduct in vivo efficacy tests of candidate decontamination systems.


Localization (neutralizing) of HD in skin
8) Confidence 0.07 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0 Pain Relevance 0.08
The existence of a reservoir of unbound HD in human skin was previously discussed.
Localization (reservoir) of HD in skin
9) Confidence 0.07 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0.20 Pain Relevance 0.03
The existence of a dermal reservoir of HD in humans was first suggested in World War 1 by Smith et al,66 who demonstrated that HD injuries could be prevented by washing contaminated skin with an appropriate solvent up to 45 minutes postexposure.
Localization (reservoir) of HD in reservoir associated with injury
10) Confidence 0.07 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0.18 Pain Relevance 0
However, studies conducted during the Second World War reported the opposite effect in that HD was rapidly “fixed” by skin constituents such as proteins.40 Contemporary in vitro studies have confirmed the original finding of Smith et al that a substantial reservoir of HD is formed in human skin that can account for up to 35% of the applied dose after 24 hours.41 This reservoir has been localized to the stratum corneum and upper epidermis.
Localization (reservoir) of HD in skin
11) Confidence 0.07 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0.27 Pain Relevance 0
Quantification and localization of the HD depot responsible for this lengthy off-gassing in this animal model has not been performed.
Localization (localization) of HD
12) Confidence 0.07 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0.17 Pain Relevance 0
High abundance of antisense transcripts for ApoE receptor and huntingtin were found in the L7 motoneuron but not other tested cells.
Localization (abundance) of huntingtin in motoneuron
13) Confidence 0.04 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2910937 Disease Relevance 0.06 Pain Relevance 0

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