INT193609

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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.77
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (HBEGF) extracellular space (HBEGF) extracellular region (HBEGF)
plasma membrane (HBEGF)
Anatomy Link Frequency
IL2R 1
Keratinocytes 1
HBEGF (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 15 91.60 High High
Potency 1 75.56 Quite High
tolerance 1 71.64 Quite High
Paracetamol 3 58.08 Quite High
Inflammation 6 19.44 Low Low
cytokine 6 18.40 Low Low
ischemia 3 15.60 Low Low
imagery 6 5.00 Very Low Very Low Very Low
pruritus 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diphtheria 7 100.00 Very High Very High Very High
Injury 198 99.96 Very High Very High Very High
Death 3 97.96 Very High Very High Very High
Apoptosis 2 97.28 Very High Very High Very High
Lymphatic System Cancer 39 88.96 High High
Wound Healing 48 88.32 High High
Adhesions 9 83.20 Quite High
Targeted Disruption 3 77.28 Quite High
Asthenia 2 69.44 Quite High
Fever 2 68.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown in vitro that stromelysin, or MMP-3,15 is able to cleave HbEGF at the juxtamembrane site, releasing the mature, soluble form of the growth factor to signal in a paracrine or juxtacrine fashion.
Protein_catabolism (cleave) of HbEGF
1) Confidence 0.30 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501117 Disease Relevance 0.44 Pain Relevance 0.04
In response to injury, HbEGF is cleaved and released by extracellular MMP-3, or Stromelysin I.15 Keratinocytes also produce MMP-1, MMP-2 and MMP-9, all of which help to remodel the matrix, allowing cells to migrate into and close the wound.9,16–18 MMP production is stimulated by the presence of target substrates and growth factors,.9,16,19–21 and MMP-1 can also be bound by integrin ?
Protein_catabolism (cleaved) of HbEGF in Keratinocytes associated with injury
2) Confidence 0.30 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501117 Disease Relevance 0.91 Pain Relevance 0.09
Interestingly, MMP-3 cleaves HbEGF successfully, but MMP-2 and MMP-9 do not.
Protein_catabolism (cleaves) of HbEGF
3) Confidence 0.30 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501117 Disease Relevance 0.36 Pain Relevance 0.04
Once denileukin diftitox binds to IL2R, this molecule is internalized into the cell where the truncated diphtheria toxin is cleaved off, liberated into the cytosol, and induces cell death by causing apoptosis.
Protein_catabolism (cleaved) of diphtheria toxin in IL2R associated with apoptosis, diphtheria and death
4) Confidence 0.01 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 1.06 Pain Relevance 0.13

General Comments

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