INT193663

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 8.84
Pain Relevance 8.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 1
respiratory 1
Pain1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 803 100.00 Very High Very High Very High
Lasting pain 149 100.00 Very High Very High Very High
Endogenous opioid 13 99.68 Very High Very High Very High
Pain matrix 1 97.68 Very High Very High Very High
Chronic low back pain 18 85.76 High High
Pain threshold 54 76.24 Quite High
tolerance 20 64.72 Quite High
Spinal cord 2 64.72 Quite High
Opioid 46 60.20 Quite High
cytokine 19 59.40 Quite High
Disease Link Frequency Relevance Heat
Pain 989 100.00 Very High Very High Very High
Somatoform Disorder 6 100.00 Very High Very High Very High
Loss Of Sense Of Smell 1 99.60 Very High Very High Very High
Pneumoperitoneum 1 99.32 Very High Very High Very High
Mediastinal Emphysema 1 98.90 Very High Very High Very High
Pneumothorax 1 98.52 Very High Very High Very High
Barotrauma 4 98.22 Very High Very High Very High
Renal Disease 3 95.24 Very High Very High Very High
Pressure Volume 2 Under Development 2 91.88 High High
Nociception 53 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It should be pointed out that MyD88-dependent receptor activation is required for the formation of autoantibody-autoantigen immune complexes in adaptive immune responses [58].
auto Binding (complexes) of
1) Confidence 0.36 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.42 Pain Relevance 0.06
From our former study and from the findings presented here, post-operative pain is suggested as being the cause of the alterations in physiology and behavior, although symptoms of pain were not apparent upon short-term (2–10?
pain Binding (symptoms) of associated with pain
2) Confidence 0.29 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2965018 Disease Relevance 0.93 Pain Relevance 0.93
The responsibility to ensure the care and welfare of the millions of animals used annually in biomedical research (Baumans, 2004, 2005) requires the recognition and alleviation of pain caused by animal experiments (Gauthier and Griffin, 2005).
pain Binding (recognition) of associated with pain
3) Confidence 0.28 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2965018 Disease Relevance 0.48 Pain Relevance 0.48
In order to test the second hypothesis, interactions between pain status and the gene polymorphisms were added.
pain Binding (interactions) of associated with pain
4) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 0.38 Pain Relevance 0.38
A significant interaction between pain status (chronic pain patients vs. pain-free controls) and the Met allele was found modeling the N2-component of C4 (B?
pain Binding (interaction) of associated with pain and lasting pain
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 0.95 Pain Relevance 0.95
A significant interaction between pain status (chronic pain patients vs. pain-free controls) and the Met allele was found modeling the N2-component of C4 (B?
pain Binding (interaction) of associated with pain and lasting pain
6) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 0.95 Pain Relevance 0.95
There was, however, again a significant interaction between pain status and the Met allele at several locations.
pain Binding (interaction) of associated with pain
7) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 1.61 Pain Relevance 1.66
An explanation concerning the COMT Val158Met polymorphism might be alterations in endogenous opioid system that is associated with chronic pain complaints [46].
pain Spec (might) Binding (associated) of associated with lasting pain and endogenous opioid
8) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 0.62 Pain Relevance 0.69
Therefore, any influence of genetic polymorphisms was assessed in interaction with clinical pain disorder.
pain Binding (interaction) of associated with pain
9) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 1.02 Pain Relevance 1.02
Unlike other sensory
               modalities, such as vision, hearing, and smell, the brain regions associated with
               pain perception are complex and have been best described as a pain matrix [3]. 
pain Binding (associated) of in brain associated with pain, pain matrix and loss of sense of smell
10) Confidence 0.01 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 1.00 Pain Relevance 0.91
These changes can lead to hypotension especially soon after intubation when other factors like sedatives and hypovolumia may be coexisting.Regions of hyperinflated lung may compress adjacent areas of normal lung and adversely affect ventilation/perfusion relationships (Brandolese 1993; Rossi 1995).DHI and auto-PEEP may predispose patients to barotrauma – Pneumothorax, pneumomediastinum and pneumoperitoneum may occur (Pepe 1982).Failure to recognize auto-PEEP and adjust for it can lead to inappropriate treatment:

- Misinterpretation of central venous and pulmonary artery catheter pressure measurements (Pepe 1982).- Erroneous calculations of static respiratory compliance: the true value of static compliance will be underestimated in the presence of auto-PEEP (Roussos 1982).

auto-PEEP Binding (recognize) of in respiratory associated with pressure volume 2 under development, barotrauma, mediastinal emphysema, pneumothorax and pneumoperitoneum
11) Confidence 0.01 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699957 Disease Relevance 0.49 Pain Relevance 0

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