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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.83
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Stat4) signal transduction (Stat4) nucleus (Stat4)
DNA binding (Stat4) cytoplasm (Stat4) signal transducer activity (Stat4)
Anatomy Link Frequency
Th1 cells 1
lymphocyte 1
NK cells 1
Stat4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 122 91.64 High High
Inflammation 161 91.24 High High
Central nervous system 48 86.56 High High
tolerance 20 59.68 Quite High
Spinal cord 6 47.60 Quite Low
agonist 44 38.44 Quite Low
Multiple sclerosis 24 19.88 Low Low
Arthritis 33 5.00 Very Low Very Low Very Low
chemokine 14 5.00 Very Low Very Low Very Low
Crohn's disease 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 70 96.04 Very High Very High Very High
Necrosis 11 92.28 High High
Cancer 61 91.92 High High
INFLAMMATION 170 91.24 High High
Disease 100 86.92 High High
Multiple Sclerosis 36 86.00 High High
Targeted Disruption 10 74.44 Quite High
Thymoma 1 72.60 Quite High
Malignant Neoplastic Disease 10 65.60 Quite High
Central Nervous System Disease 5 58.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B cannot induce transcription of twist1 on their own, but require concerted binding of activated STAT4 to the promoter of twist1.
Positive_regulation (activated) of STAT4
1) Confidence 0.47 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.18 Pain Relevance 0.09
For the initial expression of twist1 in Th1 cells, and its imprinting for reexpression in further restimulations, the concerted action of activated STAT4, NFAT1, and NF-?
Positive_regulation (activated) of STAT4 in Th1 cells
2) Confidence 0.31 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
activation of Jak2, Tyk2, Stat3, and Stat4 in T and NK cells [98, 99].
Positive_regulation (activation) of Stat4 in NK cells
3) Confidence 0.28 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 0.47 Pain Relevance 0.24
Serine phosphorylation is required for full activation of STAT4-induced transcription and IFN-?
Positive_regulation (activation) of STAT4
4) Confidence 0.16 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.07 Pain Relevance 0.08
under regulation by IL-12, which activates the lymphocyte transcription factor STAT4 (signal transducer and activator of transcription 4) and plays a significant role in the onset of autoimmunity.
Positive_regulation (activates) of factor STAT4 in lymphocyte associated with autoimmune disease
5) Confidence 0.01 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 1.11 Pain Relevance 0.24

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