INT193669

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Context Info
Confidence 0.22
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 6.40
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Pvrl1) plasma membrane (Pvrl1)
Anatomy Link Frequency
embryo 2
basal cells 2
Macrophages 1
immune cells 1
B-cells 1
Pvrl1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 290 99.96 Very High Very High Very High
chemokine 15 99.40 Very High Very High Very High
Inflammatory response 18 98.04 Very High Very High Very High
corticosteroid 17 84.36 Quite High
imagery 27 50.00 Quite Low
Inflammation 203 30.40 Quite Low
tolerance 61 27.16 Quite Low
halothane 6 18.68 Low Low
Bile 3 5.24 Low Low
Pain 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cold Sores 360 98.88 Very High Very High Very High
INFLAMMATION 221 97.68 Very High Very High Very High
Infection 206 93.72 High High
Aspergillus Infection 43 87.08 High High
Fever 12 86.72 High High
Disease Progression 5 84.40 Quite High
Graft Vs Host Disease 2 82.12 Quite High
Fungal Infection 8 81.92 Quite High
Emergencies 3 81.88 Quite High
Disease 53 80.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nectin-1 is also heavily expressed on cell surfaces during epithelial remodelling in the mouse embryo [46], which again suggests nectin-1 may be heavily expressed during the regeneration of vaginal epithelial cell layers.
Gene_expression (expressed) of Nectin-1 in embryo
1) Confidence 0.22 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1523343 Disease Relevance 0.57 Pain Relevance 0
Nectin-1 is also heavily expressed on cell surfaces during epithelial remodelling in the mouse embryo [46], which again suggests nectin-1 may be heavily expressed during the regeneration of vaginal epithelial cell layers.
Gene_expression (expressed) of nectin-1 in embryo
2) Confidence 0.22 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1523343 Disease Relevance 0.53 Pain Relevance 0
In the human vagina, nectin-1 is expressed most intensely in deeper cell layers, the stratum spinosum, the layer of maturing cells just above the basal cells, and is expressed closer to the luminal surface during epithelial regeneration in the secretory phase of the cycle [45].
Gene_expression (expressed) of nectin-1 in basal cells
3) Confidence 0.22 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1523343 Disease Relevance 0.69 Pain Relevance 0
In the human vagina, nectin-1 is expressed most intensely in deeper cell layers, the stratum spinosum, the layer of maturing cells just above the basal cells, and is expressed closer to the luminal surface during epithelial regeneration in the secretory phase of the cycle [45].
Gene_expression (expressed) of nectin-1 in basal cells
4) Confidence 0.22 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1523343 Disease Relevance 0.68 Pain Relevance 0
A possible mechanism for both the early and late phases of increased susceptibility that occur following epithelial exfoliation caused by detergents is suggested by the following findings regarding nectin-1, a major cell-surface entry receptor for HSV: 1) Mice are susceptible to HSV only during the stages of the estrous cycle when the vaginal epithelium expresses nectin-1, and the most susceptible stage can be maintained by treatment with Depo-Provera [45], 2) Incubating HSV with nectin-1 prior to vaginal inoculation blocked infection [45], 3) In the intact epithelium nectin-1 is primarily localized in the lateral surfaces between adjacent epithelial cells, a location where it is relatively inaccessible to HSV.
Gene_expression (expresses) of nectin-1 in lateral surfaces associated with cold sores and infection
5) Confidence 0.22 Published 2006 Journal BMC Infect Dis Section Body Doc Link PMC1523343 Disease Relevance 0.66 Pain Relevance 0
Pattern recognition receptors (PRR) on AM recognize specific fungal cell wall motifs displayed during the conidial and hyphal stages and produce cytokines and chemokines that stimulate neutrophil recruitment and subsequent antigen-specific immunity.
Gene_expression (produce) of PRR in neutrophil associated with chemokine and cytokine
6) Confidence 0.15 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC2859869 Disease Relevance 1.37 Pain Relevance 0.24
PRR are present not only in cells of the innate immune system such as macrophages and dendritic cells, but also in “non-professional” immune cells.
Gene_expression (present) of PRR in immune cells
7) Confidence 0.11 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.14 Pain Relevance 0
Macrophages, B-cells and dendritic cells (DC) express PRR.
Gene_expression (express) of PRR in dendritic cells
8) Confidence 0.09 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.29 Pain Relevance 0.03
In the analysis (see further below) both the continuous variable PRR and the binary variable of ?
Gene_expression (variable) of PRR
9) Confidence 0.04 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2364627 Disease Relevance 0.47 Pain Relevance 0
Parasitological success was defined as the absence of clinical deterioration from baseline and a PRR at 24 hours of ?
Neg (absence) Gene_expression (absence) of PRR
10) Confidence 0.04 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2364627 Disease Relevance 0.36 Pain Relevance 0
At 24 hours a large proportion of the PRR values for the artemisinins were close to 100% at 24 hours, and these were then categorised into binary observations (PRR >90% versus <90%).
Gene_expression (proportion) of PRR
11) Confidence 0.04 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2364627 Disease Relevance 0.05 Pain Relevance 0
Macrophages, B-cells and dendritic cells (DC) express PRR.
Gene_expression (express) of PRR in Macrophages
12) Confidence 0.03 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.29 Pain Relevance 0.03
Macrophages, B-cells and dendritic cells (DC) express PRR.
Gene_expression (express) of PRR in B-cells
13) Confidence 0.03 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.29 Pain Relevance 0.03

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