INT193672

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 2.75
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prdx2) mitochondrion (Prdx2) oxidoreductase activity (Prdx2)
cytoplasm (Prdx2)
Anatomy Link Frequency
cornea 1
Prdx2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 139 97.76 Very High Very High Very High
fibrosis 35 94.32 High High
cytokine 44 78.00 Quite High
Pain 4 66.08 Quite High
sodium channel 6 53.12 Quite High
Calcium channel 8 49.92 Quite Low
antagonist 1 17.28 Low Low
imagery 5 5.12 Low Low
tolerance 20 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroma 79 99.68 Very High Very High Very High
INFLAMMATION 139 97.76 Very High Very High Very High
Stress 55 96.48 Very High Very High Very High
Radiation Sickness 5 95.64 Very High Very High Very High
Cirrhosis 5 94.32 High High
Disease 22 93.40 High High
Fibrosis 41 88.48 High High
Cancer 60 87.68 High High
Injury 10 79.04 Quite High
Burns 50 72.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the absence of TSA, pSmad2 was detected in cell nuclei at 0.5 and 1.0 h post-TGF?
Neg (absence) Gene_expression (absence) of TSA
1) Confidence 0.50 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0 Pain Relevance 0.04
1 expression by TSA is due to the reduction of collagen in TSA-culture.
Gene_expression (expression) of TSA
2) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.15 Pain Relevance 0.07
1, presumably expressed mainly in macrophages, and collagen I, a major fibrogenic product expressed by myofibroblasts, in a TSA-treated healing cornea.
Gene_expression (expressed) of TSA in cornea
3) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.29 Pain Relevance 0.11
Evaluation of the gene expression pattern showed that systemic TSA inhibited the appearance of myofibroblasts, as detected by ?
Gene_expression (systemic) of TSA
4) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.33 Pain Relevance 0.13
Although the mechanism is not fully understood, it might include suppression of Smad-mediated gene expression by TSA.
Gene_expression (expression) of TSA
5) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.68 Pain Relevance 0.19
Similarly, the increased expression of peroxiredoxin 2 during neuroma formation was also confirmed, as was vimentin expression.
Gene_expression (expression) of peroxiredoxin 2 associated with neuroma
6) Confidence 0.07 Published 2008 Journal Mol Pain Section Body Doc Link PMC2525634 Disease Relevance 0.82 Pain Relevance 0.09
Overexpression of thioredoxin reductase (TrxR) increases growth rates and resistance to cytotoxic agents that induce oxidative stress [109,110].
Gene_expression (Overexpression) of thioredoxin reductase associated with stress
7) Confidence 0.03 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.48 Pain Relevance 0

General Comments

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