INT193694

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr9) signal transduction (Tlr9) endoplasmic reticulum (Tlr9)
plasma membrane (Tlr9) intracellular (Tlr9) lysosome (Tlr9)
Anatomy Link Frequency
B-cell 1
IgG2a (Mus musculus)
Tlr9 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 20 87.32 High High
cytokine 19 82.00 Quite High
Inflammation 14 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
vincristine 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Disease 3 69.28 Quite High
Aspergillus Infection 1 44.92 Quite Low
Coronary Heart Disease 1 43.44 Quite Low
Dilated Cardiomyopathy 1 40.80 Quite Low
Myocardial Infarction 1 38.64 Quite Low
Infection 3 22.64 Low Low
Cancer 54 5.00 Very Low Very Low Very Low
Stress 52 5.00 Very Low Very Low Very Low
Autoimmune Disease 52 5.00 Very Low Very Low Very Low
Apoptosis 35 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concurrent activation of BCR and B-cell TLR-9 by such IgG2a is due to recognition as non-self and results in the formation of a self DNA (autoantigen)-IgG2a (autoantibody) immune complex.
IgG2a Positive_regulation (activation) of TLR-9 in B-cell
1) Confidence 0.05 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.07 Pain Relevance 0.08

General Comments

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