INT193695

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.63
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il2) extracellular region (Il2) Golgi apparatus (Ctla4)
plasma membrane (Ctla4)
Anatomy Link Frequency
cytotoxic T-lymphocyte 1
Il2 (Mus musculus)
Ctla4 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 2 78.40 Quite High
Inflammation 14 75.52 Quite High
cytokine 19 74.48 Quite High
tolerance 20 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
vincristine 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphoproliferative Disease 5 96.60 Very High Very High Very High
Lymphadenopathy 2 94.84 High High
Death 15 90.16 High High
Autoimmune Lymphoproliferative Syndrome 1 80.80 Quite High
Autoimmune Disease 52 79.04 Quite High
INFLAMMATION 14 75.52 Quite High
Apoptosis 35 72.36 Quite High
Stress 52 54.88 Quite High
Malignant Neoplastic Disease 10 46.48 Quite Low
Necrosis 6 19.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, IL-2 has been shown to upregulate CTLA-4 (cytotoxic T-lymphocyte-associated protein 4; CD152), and CTLA-4-deficienciy leads to a fatal lymphoproliferative disease that is more aggressive than the lymphoproliferative disorders caused by either IL-2 or Fas deficiency [35].
IL-2 Positive_regulation (upregulate) of CTLA-4 in cytotoxic T-lymphocyte associated with lymphoproliferative disease
1) Confidence 0.01 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 1.63 Pain Relevance 0.18

General Comments

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