INT193697

Context Info Confidence 0.02 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.84 Pain Relevance 0.12

cytosol (Apaf1, CASP9) nucleus (Apaf1, CASP9) intracellular (Apaf1, CASP9) peptidase activity (CASP9) Golgi apparatus (Apaf1) cytoplasm (Apaf1)

Apaf1 (Mus musculus) CASP9 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 19 96.92 Inflammation 14 69.84 chemokine 2 25.60 tolerance 20 12.92 halothane 2 5.00 Pain 1 5.00 Bile 1 5.00 metalloproteinase 1 5.00 vincristine 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 35 99.38 Death 15 97.20 Autoimmune Disease 52 93.28 Autoimmune Lymphoproliferative Syndrome 1 91.92 Malignant Neoplastic Disease 10 72.88 INFLAMMATION 14 69.84 Lymphadenopathy 2 62.08 Lymphoproliferative Disease 5 59.36 Necrosis 6 45.52 Cancer 54 45.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Lack of cytokine signaling has been shown to cause an increase in mitochondrial permeability and cytochrome c release; along with apoptotic protease-activating factor 1 (APAF1), cytochrome c activates caspase-9 and downstream effector caspases.

APAF1 Positive_regulation (activates) of caspase-9 associated with apoptosis and cytokine

1) Confidence 0.02 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 1.84 Pain Relevance 0.12

General Comments

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