INT193736

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.13
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTSB) mitochondrion (CTSB) extracellular space (CTSB)
extracellular region (CTSB) intracellular (CTSB) lysosome (CTSB)
Anatomy Link Frequency
fibroblasts 2
CTSB (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 75 100.00 Very High Very High Very High
Inflammation 23 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
b2 receptor 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 193 99.32 Very High Very High Very High
Down Syndrome 16 95.88 Very High Very High Very High
Infection 53 94.20 High High
Alzheimer's Dementia 3 74.96 Quite High
Stress 107 50.00 Quite Low
Malaria 19 50.00 Quite Low
Apoptosis 34 5.00 Very Low Very Low Very Low
INFLAMMATION 25 5.00 Very Low Very Low Very Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gamma-secretase inhibitor Compound E restores normal BK-dependent ERK activation in PS-1 (M146L) AD fibroblasts
Regulation (dependent) of Positive_regulation (activation) of Gamma-secretase in fibroblasts associated with disease and bradykinin
1) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.98 Pain Relevance 0.52
It is possible that the observed increase in this cathepsin B may be responsible for part of the decrease in vitellogenin protein observed late in the first gonotrophic cycle and during the second gonotrophic cycle following infection with Plasmodium [18].
Spec (may) Regulation (responsible) of Positive_regulation (increase) of cathepsin B associated with infection
2) Confidence 0.01 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1508153 Disease Relevance 0.15 Pain Relevance 0

General Comments

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