INT193777

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Context Info
Confidence 0.13
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.26
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf1) cytoplasm (Fgf1) cytosol (Fgf1)
extracellular space (Fgf1) extracellular region (Fgf1) proteinaceous extracellular matrix (Fgf1)
Anatomy Link Frequency
palate 1
mast cells 1
Fgf1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 9 64.56 Quite High
Osteoarthritis 11 62.28 Quite High
fibrosis 16 55.12 Quite High
midbrain 11 42.32 Quite Low
cytokine 3 34.08 Quite Low
Opioid 7 19.68 Low Low
Glutamate 26 5.00 Very Low Very Low Very Low
antagonist 17 5.00 Very Low Very Low Very Low
nMDA receptor 12 5.00 Very Low Very Low Very Low
Action potential 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 43 98.60 Very High Very High Very High
Stress 28 98.12 Very High Very High Very High
Cancer 90 98.00 Very High Very High Very High
Targeted Disruption 28 96.88 Very High Very High Very High
Apoptosis 58 96.00 Very High Very High Very High
Hypoxia 31 94.72 High High
Colon Cancer 1 93.32 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 89 90.88 High High
Viral Meningitis 2 90.56 High High
Congenital Anomalies 9 87.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sprouty (Spry) was originally identified in Drosophila as a negative regulator of FGF signaling in tracheal development [9].
Negative_regulation (regulator) of FGF
1) Confidence 0.13 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.22 Pain Relevance 0
Finally, Welsh et al. [10,43] demonstrated that an inhibitor of FGF signaling, SPRY2, is necessary to restrict the proliferation rate in the palate and to achieve the normal pattern of rugae.
Negative_regulation (inhibitor) of FGF in palate
2) Confidence 0.10 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0.10 Pain Relevance 0
To test the requirement of FGF signaling, we treated some of the cells with 5 ┬ÁM SU5402, a chemical inhibitor of FGF receptors, added at days 4, 6 and 8 of differentiation.
Negative_regulation (inhibitor) of FGF
3) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912324 Disease Relevance 0.19 Pain Relevance 0
The fibrotic tissue also contained nitrosylated proteins concordant with elevated numbers of chymase and FGF producing mast cells, indicative of oxidative stress and increased fibroproliferative factors driving cell survival and proliferation.
Negative_regulation (numbers) of FGF in mast cells associated with stress and fibrosis
4) Confidence 0.07 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2940819 Disease Relevance 1.13 Pain Relevance 0.06
The anti-tumor activity of SU6668 has been attributed to its antiangiogenic potential arising from its inhibitory effect on the receptor-tyrosine kinase activity of VEGF, FGF, and PDGF.
Negative_regulation (effect) of FGF associated with cancer
5) Confidence 0.03 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1832206 Disease Relevance 1.97 Pain Relevance 0
Inhibitors of FGF receptor kinase attenuate the effects of FGF on CXCR4 receptor density [31].
Negative_regulation (Inhibitors) of FGF
6) Confidence 0.02 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 0.65 Pain Relevance 0.06

General Comments

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