INT193778

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.98
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ITIH4, CASP3) plasma membrane (ITIH4, CASP3) nucleoplasm (CASP3)
mitochondrion (CASP3) cytosol (CASP3) peptidase activity (CASP3)
ITIH4 (Homo sapiens)
CASP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 14 68.96 Quite High
Neurotransmitter 2 25.60 Quite Low
Glutamate 24 5.00 Very Low Very Low Very Low
nMDA receptor 12 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
Opioid 7 5.00 Very Low Very Low Very Low
Dopamine 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 41 98.44 Very High Very High Very High
Apoptosis 21 96.44 Very High Very High Very High
Drug Induced Neurotoxicity 37 89.12 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 89 76.48 Quite High
Dementia 22 73.84 Quite High
Infection 6 55.16 Quite High
Stress 17 31.20 Quite Low
Death 24 20.04 Low Low
Disease 6 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
inhibitor Z-DEVD-FMK significantly reduces gp120-induced elevations in caspase-3, but had no significant effect on Tat toxicity.
gp120-induced Positive_regulation (elevations) of caspase-3 associated with toxicity
1) Confidence 0.03 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 0.98 Pain Relevance 0.03

General Comments

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