INT193779

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Context Info
Confidence 0.19
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.83
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ITIH4, CXCR4) cytoplasm (ITIH4, CXCR4) extracellular region (ITIH4)
cytoplasmic membrane-bounded vesicle (CXCR4) signal transducer activity (CXCR4)
Anatomy Link Frequency
neurons 4
ITIH4 (Homo sapiens)
CXCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 12 95.88 Very High Very High Very High
chemokine 18 55.16 Quite High
Glutamate 48 40.40 Quite Low
antagonist 28 19.36 Low Low
nMDA receptor 24 5.00 Very Low Very Low Very Low
Opioid 14 5.00 Very Low Very Low Very Low
Dopamine 12 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Analgesic 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 82 90.36 High High
Necrosis 2 69.64 Quite High
Cancer 6 69.28 Quite High
Death 48 67.04 Quite High
Apoptosis 42 66.64 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 178 50.00 Quite Low
Drug Induced Neurotoxicity 74 50.00 Quite Low
Viral Meningitis 4 42.28 Quite Low
Neurodegenerative Disease 8 21.40 Low Low
Dementia 44 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of CXCR4 by gp120 stimulates p53 and increases the phosphorylation of Apaf-1 (proapoptotic) in neurons [35].
Positive_regulation (increases) of gp120 Positive_regulation (Stimulation) of CXCR4 in neurons
1) Confidence 0.19 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 0.42 Pain Relevance 0.08
Stimulation of CXCR4 by gp120 stimulates p53 and increases the phosphorylation of Apaf-1 (proapoptotic) in neurons [35].
Positive_regulation (stimulates) of gp120 Positive_regulation (Stimulation) of CXCR4 in neurons
2) Confidence 0.19 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 0.42 Pain Relevance 0.08

General Comments

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