INT193801

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.56
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
brain 1
astrocytes 1
microglia 1


Pain Term Frequency Confidence Heat
chemokine 27 98.68 Very High Very High Very High
Nerve growth factor 2 79.12 Quite High
Central nervous system 42 77.40 Quite High
Dopamine 6 74.48 Quite High
Inflammation 21 70.00 Quite High
Multiple sclerosis 3 60.56 Quite High
Neurotransmitter 2 59.92 Quite High
Opioid 7 52.32 Quite High
dexamethasone 2 30.60 Quite Low
Glutamate 24 19.20 Low Low
Disease Term Frequency Confidence Heat
Adhesions 22 99.60 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 309 99.58 Very High Very High Very High
Cytomegalovirus Infection 24 98.36 Very High Very High Very High
Viral Meningitis 38 98.08 Very High Very High Very High
Dementia 56 97.76 Very High Very High Very High
Toxicity 41 90.00 High High
Stress 21 87.60 High High
Death 26 84.48 Quite High
Drug Induced Neurotoxicity 41 80.16 Quite High
Disease 25 77.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These modifications allow for Tat-independent transcription with no measurable effect on viral titers, and eliminate the cis-acting promoter influence in vivo.
Transcription (transcription) of Tat
1) Confidence 0.67 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765473 Disease Relevance 0.22 Pain Relevance 0
Additionally, mRNA levels for Tat are also elevated in brain tissue of patients with HIV dementia [73].
Transcription (levels) of Tat in brain associated with dementia and acquired immune deficiency syndrome or hiv infection
2) Confidence 0.52 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 1.54 Pain Relevance 0.12
This investigation also revealed that HIV-1 transactivator of transcription (Tat) induced adhesion molecules and chemokines in astrocytes and microglia which may further increase the trafficking of PBMC into the brain.
Transcription (transcription) of Tat in astrocytes associated with chemokine, acquired immune deficiency syndrome or hiv infection and adhesions
3) Confidence 0.52 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.90 Pain Relevance 0.22
This investigation also revealed that HIV-1 transactivator of transcription (Tat) induced adhesion molecules and chemokines in astrocytes and microglia which may further increase the trafficking of PBMC into the brain.
Transcription (transcription) of Tat in microglia associated with chemokine, acquired immune deficiency syndrome or hiv infection and adhesions
4) Confidence 0.18 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.90 Pain Relevance 0.22

General Comments

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