INT193805

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.98
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ITIH4) plasma membrane (ITIH4) cytoplasm (ITIH4)
Anatomy Link Frequency
urine 4
ITIH4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 12 100.00 Very High Very High Very High
interstitial cystitis 2 93.64 High High
Chronic pancreatitis 2 92.52 High High
antagonist 28 78.00 Quite High
Glutamate 48 77.56 Quite High
Opioid 14 60.88 Quite High
Neurotransmitter 4 57.48 Quite High
Glutamate receptor 6 24.40 Low Low
chemokine 18 14.72 Low Low
nMDA receptor 24 9.36 Low Low
Disease Link Frequency Relevance Heat
Cancer 44 98.48 Very High Very High Very High
Dementia 44 98.48 Very High Very High Very High
Ovarian Cancer 58 98.40 Very High Very High Very High
Disease 18 97.88 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 178 97.80 Very High Very High Very High
Renal Disease 2 94.64 High High
Toxicity 82 93.84 High High
Interstitial Cystitis 2 93.64 High High
Pancreatitis 2 92.52 High High
Cervical Cancer 2 67.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The precise reason for the reduced levels of the ITIH4 fragment in the urine of patients with ovarian carcinoma that is observed in this study is currently not understood.
Negative_regulation (reduced) of Gene_expression (levels) of ITIH4 in urine associated with ovarian cancer
1) Confidence 0.42 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2998473 Disease Relevance 1.19 Pain Relevance 0.19
Significant reduced levels of CD59, kininogen-1 and a 39 kDa fragment of inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4), and enhanced excretion of a 19 kDa fragment of albumin, were detected in the urine of patients with ovarian carcinoma compared to the control subjects.
Negative_regulation (reduced) of Gene_expression (levels) of ITIH4 in urine associated with ovarian cancer
2) Confidence 0.42 Published 2010 Journal Proteome Sci Section Abstract Doc Link PMC2998473 Disease Relevance 0.53 Pain Relevance 0
symptoms could be loss of dopamine transporters/function following gp120 and Tat exposure.
Negative_regulation (following) of Gene_expression (exposure) of gp120 associated with dopamine
3) Confidence 0.30 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 1.13 Pain Relevance 0.29
symptoms could be loss of dopamine transporters/function following gp120 and Tat exposure.
Negative_regulation (loss) of Gene_expression (exposure) of gp120 associated with dopamine
4) Confidence 0.30 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 1.14 Pain Relevance 0.29

General Comments

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