INT193806

Context Info Confidence 0.03 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.03 Pain Relevance 0.04

response to stress (MAP3K4) cytoplasm (MAP3K4)

MAP3K4 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 2 73.92 antagonist 14 31.56 dexamethasone 2 15.84 Glutamate 24 5.00 nMDA receptor 12 5.00 chemokine 9 5.00 Opioid 7 5.00 Dopamine 6 5.00 agonist 6 5.00 cytokine 3 5.00

Disease Link Frequency Relevance Heat Toxicity 41 99.92 Dementia 22 96.20 Acquired Immune Deficiency Syndrome Or Hiv Infection 89 95.52 Feminization 1 85.40 Cancer 3 84.32 Drug Induced Neurotoxicity 37 50.00 Stress 17 27.64 Disease 6 19.72 Death 24 5.00 Apoptosis 21 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

unknown mechanism, but appears to ameliorate TNF-alpha toxicity by increasing activation of ERK-MAP kinase [87].

Positive_regulation (increasing) of Positive_regulation (activation) of ERK-MAP kinase associated with toxicity

1) Confidence 0.03 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 1.03 Pain Relevance 0.04

General Comments

This test has worked.