INT193807

Context Info Confidence 0.13 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.12 Pain Relevance 0.07

response to stress (MAP3K4) cytoplasm (MAP3K4)

Anatomy Link Frequency T cells 1 MAP3K4 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 2 73.92 cytokine 37 63.80 antagonist 14 31.12 dexamethasone 2 15.40 Inflammation 33 5.00 Glutamate 24 5.00 nMDA receptor 12 5.00 chemokine 9 5.00 Opioid 7 5.00 Dopamine 6 5.00

Disease Link Frequency Relevance Heat Toxicity 41 99.70 Stress 23 98.60 Dementia 22 95.76 Acquired Immune Deficiency Syndrome Or Hiv Infection 89 95.08 Feminization 1 84.96 Cancer 6 83.88 Drug Induced Neurotoxicity 37 50.00 Disease 16 19.28 INFLAMMATION 34 5.00 Death 25 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It has been suggested that in T cells, the classical pathway in which GADD45 proteins activate MEKK4 might be induced predominantly by stress signals, whereas the alternative pathway might be activated by TCR stimulation [31].

Positive_regulation (activate) of MEKK4 in T cells associated with stress

1) Confidence 0.13 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.10 Pain Relevance 0.03

unknown mechanism, but appears to ameliorate TNF-alpha toxicity by increasing activation of ERK-MAP kinase [87].

Positive_regulation (activation) of ERK-MAP kinase associated with toxicity

2) Confidence 0.03 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 1.02 Pain Relevance 0.04

General Comments

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