INT193811

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 7.68
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (CXCR4) plasma membrane (CXCR4) cytoplasm (CXCR4)
signal transducer activity (CXCR4)
Anatomy Link Frequency
mononuclear cells 1
CXCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 104 99.92 Very High Very High Very High
chemokine 60 90.32 High High
agonist 12 80.56 Quite High
headache 9 78.32 Quite High
Inflammation 19 61.52 Quite High
cytokine 7 51.40 Quite High
metalloproteinase 3 48.60 Quite Low
Glutamate 24 5.00 Very Low Very Low Very Low
nMDA receptor 12 5.00 Very Low Very Low Very Low
adenocard 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 51 99.92 Very High Very High Very High
Sprains And Strains 35 99.88 Very High Very High Very High
Infection 94 99.28 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 501 98.56 Very High Very High Very High
Disease 27 98.52 Very High Very High Very High
Metastasis 43 96.40 Very High Very High Very High
Breast Cancer 25 95.92 Very High Very High Very High
Dementia 22 93.64 High High
Drug Induced Neurotoxicity 37 93.12 High High
Cancer 123 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
not only for the use of CXCR4 as a general marker for the progression and
Localization (use) of CXCR4
1) Confidence 0.75 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.90 Pain Relevance 0.03
CCR5 antagonists only work against M-tropic strains of HIV, which are typically found in the early stages of infection. 17 This is due to their exclusive use of CCR5 coreceptors, rather than CXCR4, which is found in later stages of HIV.17 Therefore, maraviroc should only be used in patients with CCR5-tropic strains, and in not those which are CXCR4- tropic, dual-tropic, or mixed-tropic.
Localization (use) of CXCR4 associated with antagonist, acquired immune deficiency syndrome or hiv infection, sprains and strains and infection
2) Confidence 0.50 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2952481 Disease Relevance 1.37 Pain Relevance 0.18
Variants may exclusively use the CCR5 coreceptor (CCR5-tropic or R5 viruses) or exclusively use the CXCR4 coreceptor (CXCR4-tropic or X4 viruses).
Localization (use) of CXCR4
3) Confidence 0.44 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012555 Disease Relevance 0.65 Pain Relevance 0
Variants may exclusively use the CCR5 coreceptor (CCR5-tropic or R5 viruses) or exclusively use the CXCR4 coreceptor (CXCR4-tropic or X4 viruses).
Localization (use) of CXCR4-tropic
4) Confidence 0.44 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012555 Disease Relevance 0.71 Pain Relevance 0
Use of a novel CXCR4
Localization (Use) of CXCR4
5) Confidence 0.36 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 0.93 Pain Relevance 0.13
Dual or mixed (D/M) strains, also known as R5X4 strains, can use both CCR5 and CXCR4.


Localization (use) of CXCR4 associated with sprains and strains
6) Confidence 0.36 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504054 Disease Relevance 1.37 Pain Relevance 0.24
Removal of cholesterol from mononuclear cells reduces CD4 and CXCR4 co-localization with actin and cell susceptibility to virus-induced membrane fusion [45].
Localization (localization) of CXCR4 in mononuclear cells
7) Confidence 0.30 Published 2009 Journal Trials Section Body Doc Link PMC2705367 Disease Relevance 0.76 Pain Relevance 0

General Comments

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