INT193814

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.08
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (CXCR4) plasma membrane (CXCR4) cytoplasm (CXCR4)
signal transducer activity (CXCR4)
Anatomy Link Frequency
bone marrow 2
CXCR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 8 79.64 Quite High
chemokine 207 76.32 Quite High
Glutamate 24 71.92 Quite High
Inflammation 23 65.36 Quite High
antagonist 32 50.88 Quite High
nMDA receptor 12 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Opioid 7 5.00 Very Low Very Low Very Low
Dopamine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 20 99.96 Very High Very High Very High
Breast Cancer 20 97.22 Very High Very High Very High
Ovarian Cancer 170 92.04 High High
Disease 22 91.04 High High
Cancer 315 88.44 High High
Hematologic Neoplasms 2 88.16 High High
Prostate Cancer 2 78.72 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 97 77.84 Quite High
Drug Induced Neurotoxicity 37 76.88 Quite High
Glioblastoma 4 74.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stromal cells within bone marrow microenvironment constitutively secrete CXCL12 and the activation of CXCR4 induces leukemia cell migration to the marrow microenvironment, providing growth and drug resistance signals.
Positive_regulation (induces) of Positive_regulation (activation) of CXCR4 in bone marrow associated with leukemia
1) Confidence 0.38 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.53 Pain Relevance 0.03
A similar mechanism was also demonstrated in breast cancer cell lines, showing that estrogen-dependent proliferation involves the synthesis of CXCL12 (identified as estradiol-dependent gene), that causes an autocrine stimulation of CXCR4 and the subsequent activation of c-Src that, in turn, induces a ligand-independent activation of EGFR and ERK1/2 phosphorylation [41].
Positive_regulation (causes) of Positive_regulation (stimulation) of CXCR4 associated with breast cancer
2) Confidence 0.35 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.85 Pain Relevance 0.20
Therefore, stimulation of the CXCR4 receptor could result in activation of different p53
Positive_regulation (result) of Positive_regulation (stimulation) of CXCR4 receptor
3) Confidence 0.24 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 0.69 Pain Relevance 0.16

General Comments

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