INT193823

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Context Info
Confidence 0.18
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 7.74
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TP63) nucleoplasm (TP63) anatomical structure formation involved in morphogenesis (TP63)
Golgi apparatus (TP63) nucleolus (TP63) nucleus (TP63)
Anatomy Link Frequency
neurons 4
skin 2
lung 2
TP63 (Homo sapiens)
TP63 - P1308L (2)
Pain Link Frequency Relevance Heat
hyperexcitability 4 99.96 Very High Very High Very High
dorsal root ganglion 62 99.40 Very High Very High Very High
psoriasis 55 98.56 Very High Very High Very High
Action potential 20 98.00 Very High Very High Very High
aspirin 68 86.88 High High
Inflammation 38 84.28 Quite High
cINOD 5 81.84 Quite High
Paroxysmal extreme pain disorder 64 80.32 Quite High
Pain 35 74.88 Quite High
Neuronal excitability 4 56.64 Quite High
Disease Link Frequency Relevance Heat
Leiomyosarcoma 26 100.00 Very High Very High Very High
Ganglion Cysts 66 99.40 Very High Very High Very High
Non-small-cell Lung Cancer 2 99.24 Very High Very High Very High
Metastasis 20 99.00 Very High Very High Very High
Psoriasis 68 98.56 Very High Very High Very High
Skin Cancer 15 98.32 Very High Very High Very High
Cancer 121 97.84 Very High Very High Very High
Adenocarcinoma 25 96.04 Very High Very High Very High
Sarcoma 119 92.52 High High
Thrombocytopenia 1 87.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Three patients on this study had discernable antitumor activity, one of which was a uterine LMS patient, who experienced a 41% reduction in lung metastases and a 27% overall tumor response after four courses of 325 ?
Positive_regulation (experienced) of Gene_expression (patient) of LMS in lung associated with leiomyosarcoma, cancer and metastasis
1) Confidence 0.18 Published 2010 Journal Core evidence Section Body Doc Link PMC2899778 Disease Relevance 1.71 Pain Relevance 0
The recently discovered factor p63 is the most ancient member of the p53 family [31]. p63 amplification or overexpression is often found in NSCLC, specifically in squamous cell carcinomas [32-34].
Positive_regulation (overexpression) of Gene_expression (overexpression) of p63 associated with non-small-cell lung cancer and skin cancer
2) Confidence 0.09 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1899177 Disease Relevance 1.26 Pain Relevance 0.18
We found that p63 was not overexpressed in any lesion induced by NNK.
Neg (not) Positive_regulation (overexpressed) of Neg (not) Gene_expression (overexpressed) of p63
3) Confidence 0.09 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1899177 Disease Relevance 1.16 Pain Relevance 0.30
Immunohistochemical analyses have revealed p40 and p19 (subunits of IL-23) protein expression in dermal dendritic cells and keratinocytes of lesional psoriatic skin.31,32 Genetic studies have shown that a single nucleotide polymorphism in p40 (the common subunit of both IL-12 and IL-23)33 as well as polymorphisms in the gene encoding p1934 (IL-23 specific) was associated with the development of psoriasis.
Positive_regulation (revealed) of Gene_expression (expression) of p40 in skin associated with psoriasis
4) Confidence 0.05 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.95 Pain Relevance 0.28
We treated 9 patients with measurable LMS (primaries and
Positive_regulation (treated) of Gene_expression (treated) of LMS associated with leiomyosarcoma
5) Confidence 0.04 Published 2006 Journal Sarcoma Section Body Doc Link PMC1510952 Disease Relevance 1.68 Pain Relevance 0
Expression of either P1308L or V1298F induced hyperexcitability of DRG neurons, compared to neurons expressing WT channels.
Positive_regulation (induced) of Gene_expression (Expression) of P1308L (P1308L) in neurons associated with dorsal root ganglion and hyperexcitability
6) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2876140 Disease Relevance 0.28 Pain Relevance 0.21
However, expression of either P1308L or V1298F increased the number of DRG neurons that fired ?
Positive_regulation (increased) of Gene_expression (expression) of P1308L (P1308L) in neurons associated with dorsal root ganglion
7) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2876140 Disease Relevance 0.70 Pain Relevance 0.59

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