INT193844

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.05
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Psen1) Golgi apparatus (Psen1) endoplasmic reticulum (Psen1)
intracellular (Psen1) embryo development (Psen1) protein complex (Psen1)
Anatomy Link Frequency
cleavage 2
Psen1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 6 5.00 Very Low Very Low Very Low
sodium channel 3 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 33 53.40 Quite High
Disease 189 43.60 Quite Low
Alzheimer's Dementia 18 5.00 Very Low Very Low Very Low
Apoptosis 15 5.00 Very Low Very Low Very Low
Adhesions 15 5.00 Very Low Very Low Very Low
Frontotemporal Dementia 15 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 3 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
Disease Progression 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-secretase inhibitors do not affect PS1 endoproteolysis, providing more definite proof that PS endoproteolysis and ?
Positive_regulation (-) of Protein_catabolism (endoproteolysis) of PS1
1) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0
Experimental deletion and replacement mutants and domain swap experiments have been useful in identifying amino acid residues that are critical for PS1 endoproteolysis as well as ?
Positive_regulation (critical) of Protein_catabolism (endoproteolysis) of PS1
2) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.05 Pain Relevance 0
Interestingly, a large hydrophilic loop domain connecting the TM domain 6 and 7 (residues 304–371) of PS1, which includes a caspase cleavage site (D345) and serves as the interaction domain for several PS-associated proteins, is dispensable for PS1 endoproteolysis and ?
Positive_regulation (dispensable) of Protein_catabolism (endoproteolysis) of PS1 in cleavage
3) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0

General Comments

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