INT193849

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.92
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Psen2) endoplasmic reticulum (Psen2) embryo development (Psen2)
protein complex (Psen2) cytosol (Psen2) peptidase activity (Psen2)
Anatomy Link Frequency
MCF-7 2
Psen2 (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 20 100.00 Very High Very High Very High
Serotonin 23 86.56 High High
antidepressant 90 77.76 Quite High
fluoxetine 17 74.32 Quite High
sSRI 36 73.28 Quite High
nMDA receptor 15 69.40 Quite High
depression 56 66.32 Quite High
noradrenaline 4 63.20 Quite High
ketamine 2 59.00 Quite High
nMDA receptor antagonist 5 54.72 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 84 99.98 Very High Very High Very High
Alzheimer's Dementia 110 99.72 Very High Very High Very High
Cognitive Disorder 53 99.44 Very High Very High Very High
Cytomegalovirus Infection 4 97.60 Very High Very High Very High
Cancer 36 94.08 High High
Disease 260 92.40 High High
Death 14 82.16 Quite High
Disease Progression 2 77.48 Quite High
Breast Cancer 20 76.80 Quite High
Depression 72 67.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The PS2 mutation also accelerated learning and memory impairment associated with A?
Positive_regulation (accelerated) of Gene_expression (mutation) of PS2 associated with cognitive disorder
1) Confidence 0.44 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC3018662 Disease Relevance 0.84 Pain Relevance 0
The PS2 transgene is expressed under control of a ubiquitous CAGGS promoter consisting of cytomegalovirus early enhancer coupled with chicken ?
Positive_regulation (transgene) of Gene_expression (expressed) of PS2 associated with cytomegalovirus infection
2) Confidence 0.44 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018662 Disease Relevance 0.66 Pain Relevance 0
Here, we demonstrate that the PS2 mutation induced the early deposition of amyloid ?
Positive_regulation (induced) of Gene_expression (mutation) of PS2 associated with alzheimer's dementia
3) Confidence 0.44 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC3018662 Disease Relevance 0.86 Pain Relevance 0
In the absence of PS1, transgenic expression of wild type PS2 neither increases A?
Neg (neither) Positive_regulation (increases) of Gene_expression (expression) of PS2 associated with targeted disruption
4) Confidence 0.38 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.86 Pain Relevance 0
While the basal level of pS2 mRNA is elevated in untreated MCF-7CLU cells relative to the parental cell line, the estrogen induced expression of pS2 mRNA, and the responsiveness to tamoxifen is essentially equivalent in the parental and MCF-7CLU cell lines, indicating that clusterin over expression has not significantly altered the ability of the estrogen receptor to transactivate known target genes.
Positive_regulation (induced) of Gene_expression (expression) of pS2 mRNA
5) Confidence 0.30 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.06 Pain Relevance 0
siRNA against NCoA6(ASC-2) was used in MCF-7 cells to demonstrate the E2-dependent induction of pS2 gene expression [Ju et al., 2006].


Positive_regulation (induction) of Gene_expression (expression) of pS2 in MCF-7
6) Confidence 0.16 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.48 Pain Relevance 0
Moderate elevation in levels of intracellular amyloid peptide load leads to over expression in CREB responsive genes such as BDNF, presenilin 1 and presenilin 2.
Positive_regulation (leads) of Gene_expression (expression) of presenilin 2 associated with alzheimer's dementia and bdmf
7) Confidence 0.05 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2845130 Disease Relevance 1.15 Pain Relevance 0.76

General Comments

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