INT193862

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.90
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Psen1) Golgi apparatus (Psen1) endoplasmic reticulum (Psen1)
intracellular (Psen1) embryo development (Psen1) protein complex (Psen1)
Psen1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 20 57.76 Quite High
sodium channel 2 51.96 Quite High
cINOD 8 45.68 Quite Low
Eae 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 146 100.00 Very High Very High Very High
Apoptosis 10 92.52 High High
Targeted Disruption 24 89.92 High High
Stress 2 67.96 Quite High
Urological Neuroanatomy 2 52.96 Quite High
Alzheimer's Dementia 34 50.00 Quite Low
Adhesions 10 43.88 Quite Low
Frontotemporal Dementia 10 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, the absence of PS1 or the expression of FAD-linked PS1 mutant results in increased glycogen synthase kinase-3?
Positive_regulation (results) of Positive_regulation (absence) of PS1 associated with disease
1) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.70 Pain Relevance 0
Genetic and biochemical approaches have identified three additional proteins that are crucial for the stability of PS1 as well as ?
Positive_regulation (crucial) of Positive_regulation (stability) of PS1
2) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.09 Pain Relevance 0.03
These data suggest that fenofibrate alters the conformation of the PS1 molecule to favor a “close” PS1 NT-loop and PS1 NT-CT proximity, which correlates with a shift in the APP ?
Positive_regulation (favor) of Positive_regulation (close) of PS1
3) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.05 Pain Relevance 0.03
These data suggest that fenofibrate alters the conformation of the PS1 molecule to favor a “close” PS1 NT-loop and PS1 NT-CT proximity, which correlates with a shift in the APP ?
Positive_regulation (favor) of Positive_regulation (close) of PS1
4) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.05 Pain Relevance 0.03

General Comments

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