INT193865

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Context Info
Confidence 0.97
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 0.37
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Psen1) Golgi apparatus (Psen1) endoplasmic reticulum (Psen1)
intracellular (Psen1) embryo development (Psen1) protein complex (Psen1)
Anatomy Link Frequency
cleavage 1
Psen1 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 9 72.00 Quite High
imagery 10 40.08 Quite Low
cINOD 20 5.00 Very Low Very Low Very Low
Eae 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 100 81.92 Quite High
Adhesions 45 63.92 Quite High
Disease 577 61.12 Quite High
Alzheimer's Dementia 65 50.00 Quite Low
Apoptosis 45 7.84 Low Low
Frontotemporal Dementia 45 7.04 Low Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 9 5.00 Very Low Very Low Very Low
Stress 9 5.00 Very Low Very Low Very Low
Disease Progression 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PS1 stability and functions in ?
Protein_catabolism (stability) of PS1
1) Confidence 0.97 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.26 Pain Relevance 0.04
Experimental deletion and replacement mutants and domain swap experiments have been useful in identifying amino acid residues that are critical for PS1 endoproteolysis as well as ?
Protein_catabolism (endoproteolysis) of PS1
2) Confidence 0.86 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.05 Pain Relevance 0
In contrast, aspartate residues at position D275 (in TM6) and D385 (in TM7) of PS1 are critical for both PS1 endoproteolysis and ?
Protein_catabolism (endoproteolysis) of PS1
3) Confidence 0.86 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0
-secretase inhibitors do not affect PS1 endoproteolysis, providing more definite proof that PS endoproteolysis and ?
Protein_catabolism (endoproteolysis) of PS1
4) Confidence 0.86 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0
The enzyme activity responsible for PS1 endoproteolysis has not been identified.
Protein_catabolism (endoproteolysis) of PS1
5) Confidence 0.86 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0
Interestingly, a large hydrophilic loop domain connecting the TM domain 6 and 7 (residues 304–371) of PS1, which includes a caspase cleavage site (D345) and serves as the interaction domain for several PS-associated proteins, is dispensable for PS1 endoproteolysis and ?
Protein_catabolism (endoproteolysis) of PS1 in cleavage
6) Confidence 0.86 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0
-secretase, are cleaved by G-PS1-R containing ?
Protein_catabolism (cleaved) of G-PS1
7) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0 Pain Relevance 0
Thus, PS1 endoproteolysis, stability and accumulation of PS1 NTF/CTF are regulated by the availability of stoichiometric levels of nicastrin, APH-1 and PEN-2.
Protein_catabolism (endoproteolysis) of PS1
8) Confidence 0.64 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0
Endoproteolytic processing of PS is a highly conserved and, perhaps, a critical event that regulates the stability of PS1 and possibly the biological activity of PS.
Protein_catabolism (stability) of PS1
9) Confidence 0.64 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.06 Pain Relevance 0
Thus, PS1 endoproteolysis, stability and accumulation of PS1 NTF/CTF are regulated by the availability of stoichiometric levels of nicastrin, APH-1 and PEN-2.
Protein_catabolism (stability) of PS1
10) Confidence 0.64 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0

General Comments

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