INT193872

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.39
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Psen1) Golgi apparatus (Psen1) endoplasmic reticulum (Psen1)
intracellular (Psen1) embryo development (Psen1) protein complex (Psen1)
Anatomy Link Frequency
neurons 2
Psen1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 6 82.48 Quite High
imagery 10 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 23 100.00 Very High Very High Very High
Alzheimer's Dementia 23 99.58 Very High Very High Very High
Disease 136 93.00 High High
INFLAMMATION 3 82.08 Quite High
Death 1 81.72 Quite High
Disease Progression 2 78.56 Quite High
Adhesions 10 9.68 Low Low
Apoptosis 10 5.00 Very Low Very Low Very Low
Frontotemporal Dementia 10 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the absence of PS1, transgenic expression of wild type PS2 neither increases A?
Neg (neither) Positive_regulation (increases) of Neg (absence) Localization (absence) of PS1 associated with targeted disruption
1) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.87 Pain Relevance 0
secretion and accumulation of APP C-terminal fragments (CTF) in PS1-/- neurons.
Positive_regulation (accumulation) of Localization (secretion) of PS1 in neurons
2) Confidence 0.49 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.09 Pain Relevance 0
For example, familial AD-linked mutations in PS1, elongation of Pen2 N-terminus (NT), or expression of Aph1B isoform, increase the A?
Positive_regulation (increase) of Localization (elongation) of PS1 associated with alzheimer's dementia
3) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.43 Pain Relevance 0.08

General Comments

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