INT193886

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2006
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.06
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Psen1) Golgi apparatus (Psen1) endoplasmic reticulum (Psen1)
intracellular (Psen1) embryo development (Psen1) protein complex (Psen1)
Psen1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 6 5.00 Very Low Very Low Very Low
sodium channel 3 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 189 61.12 Quite High
Targeted Disruption 33 21.80 Low Low
Apoptosis 15 8.40 Low Low
Frontotemporal Dementia 15 7.60 Low Low
Alzheimer's Dementia 18 5.00 Very Low Very Low Very Low
Adhesions 15 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 3 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
Disease Progression 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The enzyme activity responsible for PS1 endoproteolysis has not been identified.
Regulation (responsible) of Protein_catabolism (endoproteolysis) of PS1
1) Confidence 0.44 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0
-secretase inhibitors do not affect PS1 endoproteolysis, providing more definite proof that PS endoproteolysis and ?
Neg (not) Regulation (affect) of Protein_catabolism (endoproteolysis) of PS1
2) Confidence 0.44 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0
Endoproteolytic processing of PS is a highly conserved and, perhaps, a critical event that regulates the stability of PS1 and possibly the biological activity of PS.
Spec (possibly) Regulation (regulates) of Protein_catabolism (stability) of PS1
3) Confidence 0.26 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.06 Pain Relevance 0

General Comments

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