INT193893

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.65
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Tpm1) cytoskeleton (Tpm1) embryo development (Tpm1)
protein complex (Tpm1) cytoplasm (Tpm1)
Anatomy Link Frequency
myofibril 1
TM1 1
Tpm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 16 99.48 Very High Very High Very High
Inflammation 10 90.16 High High
imagery 42 5.00 Very Low Very Low Very Low
Action potential 22 5.00 Very Low Very Low Very Low
isoflurane 8 5.00 Very Low Very Low Very Low
ischemia 7 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Thoracotomy 2 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophic Cardiomyopathy 42 100.00 Very High Very High Very High
INFLAMMATION 14 90.16 High High
Insulin Resistance 9 89.60 High High
Acidosis 6 88.80 High High
Cancer 5 83.60 Quite High
Diabetes Mellitus 5 83.28 Quite High
Sepsis 5 82.88 Quite High
Disease 77 82.36 Quite High
Chronic Renal Failure 28 81.16 Quite High
Frailty 19 79.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The initial step in this process is activation of caspase-3 to cleave the myofibril into its components (actin, myosin, troponin, and tropomyosin).
Gene_expression (actin) of tropomyosin in myofibril
1) Confidence 0.65 Published 2007 Journal Pediatr Nephrol Section Abstract Doc Link PMC2259254 Disease Relevance 1.07 Pain Relevance 0.05
We identified an HCM-causative mutation in one of the five most commonly mutated sarcomeric genes (MYH7, MYBPC3, TPM1, TNNI3, or TNNT2) in 40 cases, but we cannot exclude that other patients harbour mutations in any of the other genes that have been linked to HCM.
Gene_expression (identified) of TPM1 associated with hypertrophic cardiomyopathy
2) Confidence 0.57 Published 2010 Journal J Transl Med Section Body Doc Link PMC2907326 Disease Relevance 0.44 Pain Relevance 0.05
At the same time, we observe substantial increases in expression of 1,012 genes, including cardiac structural genes such as tropomyosin 1 and 2 (TPM1, 2, ?
Gene_expression (genes) of TPM1
3) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.07 Pain Relevance 0
At the same time, we observe substantial increases in expression of 1,012 genes, including cardiac structural genes such as tropomyosin 1 and 2 (TPM1, 2, ?
Gene_expression (expression) of TPM1
4) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.07 Pain Relevance 0
For example, deletion of TM1 through TM2 (PS1?
Gene_expression (through) of TM2 in TM1
5) Confidence 0.14 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0

General Comments

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