INT19391

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Context Info
Confidence 0.72
First Reported 1991
Last Reported 2010
Negated 5
Speculated 3
Reported most in Body
Documents 44
Total Number 47
Disease Relevance 13.99
Pain Relevance 5.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nt5e) cytoplasm (Nt5e)
Anatomy Link Frequency
neutrophils 2
cleavage 1
epithelial cells 1
fibroblast 1
Shields 1
Nt5e (Mus musculus)
Pain Link Frequency Relevance Heat
intrathecal 44 99.98 Very High Very High Very High
adenocard 334 99.70 Very High Very High Very High
Enkephalin 1 99.36 Very High Very High Very High
Inflammation 532 98.92 Very High Very High Very High
Morphine 172 98.64 Very High Very High Very High
COX2 14 98.16 Very High Very High Very High
Pain 25 98.08 Very High Very High Very High
Inflammatory response 159 97.96 Very High Very High Very High
withdrawal 53 97.04 Very High Very High Very High
Spinal cord 70 96.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sprains And Strains 499 99.76 Very High Very High Very High
INFLAMMATION 691 98.92 Very High Very High Very High
Bacterial Respiratory Disease 52 98.92 Very High Very High Very High
Nervous System Injury 66 98.88 Very High Very High Very High
Infection 388 98.76 Very High Very High Very High
Nociception 55 98.60 Very High Very High Very High
Stress 5 98.40 Very High Very High Very High
Respiratory Syncytial Virus 198 98.36 Very High Very High Very High
Fabry Disease 32 98.36 Very High Very High Very High
Renal Disease 6 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Instead, NT5E was only present in cell lysates.
Gene_expression (present) of NT5E
1) Confidence 0.72 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0.12 Pain Relevance 0
Could ENT investigations allow to predict an evolution to end-stage renal disease in patients demonstrating hearing loss?
Spec (investigations) Gene_expression (investigations) of ENT associated with deafness and renal disease
2) Confidence 0.65 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 0.93 Pain Relevance 0
EGFP-negative cells present in the cultures displayed a clearly different morphology (data not shown) and presumably were rat fibroblast cells as they were not recognized by antibodies directed against human CD29 and CD73 (Figure 7, hCD29 vs. hCD73 dot plot on EGFP-negative cells).
Gene_expression (dot) of CD73 in fibroblast
3) Confidence 0.65 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0.14 Pain Relevance 0.10
This observation suggested that exclusion of Ser523 was important for producing a soluble version of NT5E.
Gene_expression (producing) of NT5E
4) Confidence 0.63 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0 Pain Relevance 0
We thus generated a mouse NT5E (Trp29-Phe522) expression construct that was truncated just before Ser523 (Figure 1A).
Gene_expression (expression) of NT5E
5) Confidence 0.63 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0 Pain Relevance 0
Catalytic restriction limits the amount of adenosine produced and could explain why saturating doses of PAP or NT5E protein do not paralyze mice.
Gene_expression (protein) of NT5E associated with adenocard
6) Confidence 0.63 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0.14 Pain Relevance 0.68
[The effect of Leu- and Met-enkephalins on the adenosine deaminase and 5'-nucleotidase activities of the lymphocytes under conditions of stress stimulation of metastasis].
Gene_expression (activities) of 5'-nucleotidase in lymphocytes associated with stress, adenocard, enkephalin and metastasis
7) Confidence 0.61 Published 1991 Journal Fiziol Zh Section Title Doc Link 2055328 Disease Relevance 0.36 Pain Relevance 0.24
Recently, we found that NT5E is expressed in peptidergic and nonpeptidergic nociceptive (pain-sensing) neurons and their axon terminals in spinal cord and skin [9].
Gene_expression (expressed) of NT5E in neurons associated with nociception, pain and spinal cord
8) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0.68 Pain Relevance 0.40
We then measured noxious thermal and mechanical sensitivity before (baseline, BL) and after mNT5E injection.
Gene_expression (injection) of mNT5E
9) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0.20 Pain Relevance 0.44
NAS carried out the behavioral studies and drafted figure legends, MKV carried out molecular and biochemical studies and drafted portions of the manuscript, MJZ designed the mNT5E expression construct, conceived of and designed the study and wrote the manuscript.
Gene_expression (expression) of mNT5E
10) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0.31 Pain Relevance 0.17
Intrathecal injection of mNT5E did not alter mechanical sensitivity (Figure 3B) nor did it cause paralysis or sedation at any of the doses tested.
Gene_expression (injection) of mNT5E associated with sleep disorders, paralysis and intrathecal
11) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0.40 Pain Relevance 0.55
This mNT5E PCR product was subcloned in frame with an N-terminal GST fusion tag, with a single thrombin cleavage site between the GST tag and the coding sequence of mNT5E.
Gene_expression (product) of mNT5E in cleavage
12) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0.07 Pain Relevance 0.18
We performed spared nerve injury surgeries as described by Shields and colleagues [54]. mNT5E protein was diluted in 0.9% saline for intrathecal injection (5 ?
Gene_expression (diluted) of mNT5E protein in Shields associated with nervous system injury and intrathecal
13) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0.37 Pain Relevance 0.26
The supernatant containing secreted GST-mNT5E was filtered (0.45 ?
Gene_expression (filtered) of mNT5E
14) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0 Pain Relevance 0
Furthermore, we have identified a relatively large group of genes with parallel expression profiles to that of Tsc22d3 (Sgk, Klf15, Fzd2, Gpt2, Rhpn2, Nt5e, and Nfkbia), which may indicate morphine-induced co-regulation of these genes.
Gene_expression (expression) of Nt5e associated with morphine
15) Confidence 0.52 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.12 Pain Relevance 0.55
We found that SHED are capable of differentiating into osteogenic and adipogenic cells, expressing mesenchymal surface molecules (STRO-1, CD146, SSEA4, CD73, CD105, and CD166), and activating multiple signaling pathways, including TGF?
Gene_expression (expressing) of CD73 in SHED
16) Confidence 0.19 Published 2010 Journal Stem Cell Res Ther Section Abstract Doc Link PMC2873699 Disease Relevance 0.33 Pain Relevance 0
Herein, we used flow cytometry, immunoblot analysis, and immunocytostaining analysis to demonstrate that SHED at passage 3 expressed many mesenchymal surface markers, including STRO-1, SSEA4, CD73, CD105, CD146, and CD166 but were negative for CD34 and CD45 (Figures 1A-C).
Gene_expression (expressed) of CD73
17) Confidence 0.19 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0 Pain Relevance 0
These studies revealed significant induction of HIF-1-target genes (VEGF, CD73 or FN1) in control cells, while these responses were abolished in HIF-1?
Gene_expression (genes) of CD73
18) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.05 Pain Relevance 0.03
Thus, we measured transcript levels of CD73 [62], VEGF [63], Fibronectin1 (FN1) [64] and COX2 [65] after 24 h of RSV infection of A549 pulmonary epithelial cells using different RSV infection doses (MOI1-5).
Gene_expression (levels) of CD73 in epithelial cells associated with cox2, infection and respiratory syncytial virus
19) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.79 Pain Relevance 0.08
Specifically, Ent-producing K. pneumoniae elicit neutrophils in Lcn2+/+ mice without showing a defect in colonization.
Neg (without) Gene_expression (producing) of Ent in neutrophils
20) Confidence 0.11 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.26 Pain Relevance 0.16

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