INT19392

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Context Info
Confidence 0.77
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 7.40
Pain Relevance 3.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ada) extracellular space (Ada) cell adhesion (Ada)
plasma membrane (Ada) lysosome (Ada) cytoplasm (Ada)
Anatomy Link Frequency
lymphocytes 1
CFU-S 1
Ada (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 171 100.00 Very High Very High Very High
Adalimumab 8 100.00 Very High Very High Very High
Infliximab 35 99.90 Very High Very High Very High
Enkephalin 1 99.84 Very High Very High Very High
Inflammation 98 98.48 Very High Very High Very High
Etanercept 31 96.52 Very High Very High Very High
Catecholamine 1 92.96 High High
Crohn's disease 14 84.00 Quite High
Inflammatory response 11 83.88 Quite High
fibrosis 2 83.44 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 900 99.92 Very High Very High Very High
Diabetes Mellitus 36 99.08 Very High Very High Very High
Pneumonia 40 98.88 Very High Very High Very High
Stress 8 98.40 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

27 98.16 Very High Very High Very High
Metastasis 1 97.52 Very High Very High Very High
Disease 48 95.84 Very High Very High Very High
Asthma 5 95.16 Very High Very High Very High
Coronary Heart Disease 210 94.80 High High
INFLAMMATION 77 93.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Characterization of mice with elevated adenosine levels secondary to the loss of adenosine deaminase (ADA) expression, the primary metabolic enzyme for adenosine, further support a role for this ubiquitous mediator in the pathogenesis of asthma.
Gene_expression (expression) of ADA associated with asthma and adenocard
1) Confidence 0.77 Published 2007 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 17468137 Disease Relevance 0.28 Pain Relevance 0.43
Berberine, a major ingredient of OGT, suppressed ADA expression and reduced the incidence of lethality.
Gene_expression (expression) of ADA
2) Confidence 0.71 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19319464 Disease Relevance 0 Pain Relevance 0
Quantitative real time RT-PCR and in situ hybridization showed that OGT decreased the expression of ADA, which possibly resulted in the elevation of the anti-inflammatory nucleoside adenosine.
Gene_expression (expression) of ADA
3) Confidence 0.71 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19319464 Disease Relevance 0 Pain Relevance 0
[The effect of Leu- and Met-enkephalins on the adenosine deaminase and 5'-nucleotidase activities of the lymphocytes under conditions of stress stimulation of metastasis].
Gene_expression (activities) of adenosine deaminase in lymphocytes associated with stress, adenocard, enkephalin and metastasis
4) Confidence 0.60 Published 1991 Journal Fiziol Zh Section Title Doc Link 2055328 Disease Relevance 0.36 Pain Relevance 0.24
Gene-deficient mice that fail to express adenosine deaminase (ADA-/- mice) succumb to severe pulmonary inflammation at the age of 3 weeks.
Gene_expression (express) of adenosine deaminase associated with adenocard, inflammation and pneumonia
5) Confidence 0.39 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 0.99 Pain Relevance 0.85
Gene-deficient mice that fail to express adenosine deaminase (ADA-/- mice) succumb to severe pulmonary inflammation at the age of 3 weeks.
Gene_expression (express) of ADA associated with adenocard, inflammation and pneumonia
6) Confidence 0.39 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 1.00 Pain Relevance 0.86
ETC and onercept are genetically engineered fusion proteins consisting of two molecules of the natural p75 or p55 TNF receptors and the Fc domain of human IgG1, whereas IFX and ADA are IgG1 antibodies against TNF-?
Gene_expression (antibodies) of ADA associated with infliximab, adalimumab and etanercept
7) Confidence 0.26 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2452978 Disease Relevance 0.73 Pain Relevance 0.73
According to ADA and NCEP, niacin can safely be used even in patients with diabetes.
Gene_expression (used) of ADA associated with diabetes mellitus
8) Confidence 0.08 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 0.90 Pain Relevance 0
ACC and ADA published a consensus statement in 2008 that provides recommendations for patients with elevated global cardiometabolic risk (CMR).
Gene_expression (ACC) of ADA
9) Confidence 0.08 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.27 Pain Relevance 0
The most common form of dyslipidemia in the diabetics includes co-existence of high levels of TG and low serum levels of HDL.24 ADA 2008 guidelines recommend initiation of statin therapy to lifestyle therapy irrespective of the lipid levels for all diabetics who have either manifest CHD or ?
Gene_expression (guidelines) of ADA associated with diabetes mellitus, coronary heart disease and disorder of lipid metabolism
10) Confidence 0.08 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988622 Disease Relevance 1.55 Pain Relevance 0
The integration of the human ADA gene was observed during 9 months in about 60% of studied CFU-S.
Gene_expression (integration) of ADA gene in CFU-S
11) Confidence 0.08 Published 1997 Journal Blood Section Abstract Doc Link 9057667 Disease Relevance 0.07 Pain Relevance 0.06

General Comments

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