INT19393

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Context Info
Confidence 0.51
First Reported 1991
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 31
Total Number 35
Disease Relevance 18.90
Pain Relevance 3.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gfm1) intracellular (Gfm1) translation (Gfm1)
GTPase activity (Gfm1)
Anatomy Link Frequency
diaphragm 2
brain 2
astrocyte 2
respiratory 2
muscle 1
Gfm1 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 76 99.96 Very High Very High Very High
Opioid 7 99.70 Very High Very High Very High
Ultiva 16 99.48 Very High Very High Very High
adenocard 20 97.88 Very High Very High Very High
anesthesia 27 97.24 Very High Very High Very High
ischemia 59 96.88 Very High Very High Very High
addiction 11 96.64 Very High Very High Very High
alcohol 55 95.40 Very High Very High Very High
palliative 4 92.88 High High
agonist 70 86.04 High High
Disease Link Frequency Relevance Heat
Parkinson's Disease 192 100.00 Very High Very High Very High
Pressure And Volume Under Development 282 99.96 Very High Very High Very High
Injury 49 99.70 Very High Very High Very High
Brain Hemorrhage 120 99.68 Very High Very High Very High
Diabetes Mellitus 48 99.64 Very High Very High Very High
Metabolic Syndrome 28 99.38 Very High Very High Very High
Alcoholic Cardiomyopathy 15 99.28 Very High Very High Very High
Pulmonary Disease 42 98.58 Very High Very High Very High
Necrosis 58 98.32 Very High Very High Very High
Neuroblastoma 26 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that eptazocine may improve cerebral ischemic disorders through an activation and/or protection of mitochondrial energy-producing systems.
Gene_expression (producing) of mitochondrial
1) Confidence 0.51 Published 1991 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 2055580 Disease Relevance 0.51 Pain Relevance 0.26
Are fentanyl and remifentanil safe opioids for rat brain mitochondrial bioenergetics?
Gene_expression (bioenergetics) of mitochondrial in brain associated with ultiva and opioid
2) Confidence 0.47 Published 2009 Journal Mitochondrion Section Title Doc Link 19303949 Disease Relevance 0 Pain Relevance 0.95
These data provide the first indication that fentanyl and remifentanil (microg/mL range) alters mitochondrial metabolism.
Gene_expression (metabolism) of mitochondrial associated with ultiva
3) Confidence 0.47 Published 2009 Journal Mitochondrion Section Abstract Doc Link 19303949 Disease Relevance 0 Pain Relevance 0.82
Mice lacking the mitochondrial antioxidant enzyme manganese-superoxide dismutase (SOD) develop dilated cardiomyopathy.
Neg (lacking) Gene_expression (lacking) of mitochondrial associated with dilated cardiomyopathy
4) Confidence 0.29 Published 2003 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 14584751 Disease Relevance 0.92 Pain Relevance 0.09
Importantly, proteomics study defining altered protein expression in treated cells suggests the involvement of several mitochondrial proteins playing important roles in electron transfer chain, implying mitochondrial dysfunction during the treatment.
Gene_expression (dysfunction) of mitochondrial associated with parkinson's disease
5) Confidence 0.08 Published 2008 Journal Cancer Sci. Section Abstract Doc Link 19016762 Disease Relevance 1.48 Pain Relevance 0.07
Importantly, proteomics study defining altered protein expression in treated cells suggests the involvement of several mitochondrial proteins playing important roles in electron transfer chain, implying mitochondrial dysfunction during the treatment.
Gene_expression (dysfunction) of mitochondrial associated with parkinson's disease
6) Confidence 0.08 Published 2008 Journal Cancer Sci. Section Abstract Doc Link 19016762 Disease Relevance 1.45 Pain Relevance 0.07
Mendelian mitochondrial disorders can be attributed to mutations in genes that (i) encode subunits of the RC ("direct hits"); (ii) encode assembly proteins or RC complexes ("indirect hits"); (iii) encode factors needed for mtDNA maintenance, replication, or translation (intergenomic signaling); (iv) encode components of the mitochondrial protein import machinery; (v) control the synthesis and composition of mitochondrial membrane phospholipids; and (vi) encode proteins involved in mitochondrial dynamics.In contrast to this wealth of knowledge about etiology, our understanding of pathogenic mechanism is very limited.
Gene_expression (synthesis) of mitochondrial associated with mitochondrial disorders
7) Confidence 0.06 Published 2009 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 20225024 Disease Relevance 0.31 Pain Relevance 0.06
These data do not rule out an affect of 2MeSADP treatment on vascular or microglia cells, but taken as a whole, the data are more consistent with an astrocytic target and suggest that mitochondrial ATP production plays a rate-limiting role in astrocyte swelling, presumably because of the energy-dependence of ion homeostasis.
Gene_expression (production) of mitochondrial in microglia associated with addiction and pressure and volume under development
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.37 Pain Relevance 0.05
production or mitochondrial membrane potential (Fig. 3 and Fig. 4).
Gene_expression (production) of mitochondrial
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 0.22 Pain Relevance 0
Earlier in vitro work from this laboratory demonstrated that P2Y1R-enhanced astrocyte and neuronal protection was dependent on astrocyte mitochondrial ATP production [22].
Gene_expression (production) of mitochondrial in astrocyte
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.73 Pain Relevance 0
Consequently, enhancing mitochondrial metabolism in astrocytes is a relatively unexplored strategy to decrease edema and preserve the penumbra [13].
Gene_expression (metabolism) of mitochondrial in astrocytes associated with pressure and volume under development
11) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 1.10 Pain Relevance 0.03
Taken together, these reports are consistent with the hypothesis that glial mitochondrial metabolism is a key determinant of cytotoxic edema, necrosis and neuronal survival during cerebral ischemic stroke.
Gene_expression (metabolism) of mitochondrial in neuronal associated with brain hemorrhage, necrosis and pressure and volume under development
12) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 0.68 Pain Relevance 0
Altered expression of mitochondrial function and ?
Gene_expression (expression) of mitochondrial
13) Confidence 0.04 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.06 Pain Relevance 0.11
production and mitochondrial membrane potential loss following acute ethanol challenge.
Gene_expression (production) of mitochondrial
14) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 1.10 Pain Relevance 0.03
Myocardial mitochondrial damage was assessed using mitochondrial superoxide (O2•?)
Gene_expression (damage) of mitochondrial
15) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 0.93 Pain Relevance 0.08
These data suggest that 2MeSADP-induced reduction of cytotoxic edema is dependent on astrocyte mitochondrial ATP production during ischemic brain injuries.


Gene_expression (production) of mitochondrial in brain associated with brain hemorrhage and pressure and volume under development
16) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008710 Disease Relevance 1.03 Pain Relevance 0.03
Although coupling between COX-2 and mitochondrial enzymes in brain has not been reported, mitochondrial localization of COX-2 has been reported in cancer cells and in corpus luteum [12,13].
Gene_expression (enzymes) of mitochondrial in corpus luteum associated with cancer
17) Confidence 0.04 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.10 Pain Relevance 0.16
Mitochondrial function is enhanced in the diaphragm of patients with COPD (Ribera et al 2002), as indicated by increases in the maximum rate of mitochondrial respiration and efficiency of the mitochondrial electron transport chain.
Gene_expression (respiration) of mitochondrial in diaphragm associated with pulmonary disease
18) Confidence 0.03 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706598 Disease Relevance 0.55 Pain Relevance 0
Mitochondrial function is enhanced in the diaphragm of patients with COPD (Ribera et al 2002), as indicated by increases in the maximum rate of mitochondrial respiration and efficiency of the mitochondrial electron transport chain.
Gene_expression (respiration) of mitochondrial in diaphragm associated with pulmonary disease
19) Confidence 0.03 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706598 Disease Relevance 0.54 Pain Relevance 0
This is in agreement with the results of Saborido et al (1991), who found that in rat extensor digitorum longus (EDL), but not in soleus muscle, mitochondrial function was enhanced after treatment with fluoxymesterone and meth-androstanolone, suggesting a higher sensitivity for anabolic steroid in fast-twitch (EDL) muscle.
Neg (not) Gene_expression (function) of mitochondrial in EDL
20) Confidence 0.03 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706598 Disease Relevance 0 Pain Relevance 0.04

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