INT193938

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Context Info
Confidence 0.79
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.60
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PSEN1) Golgi apparatus (PSEN1) endoplasmic reticulum (PSEN1)
embryo development (PSEN1) peptidase activity (PSEN1) cell death (PSEN1)
PSEN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Eae 1 73.60 Quite High
cytokine 1 59.60 Quite High
cINOD 26 20.12 Low Low
aspirin 9 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 91 100.00 Very High Very High Very High
Targeted Disruption 13 98.76 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 90.40 High High
Amyloid Plaque 35 81.60 Quite High
Death 5 80.08 Quite High
Stress 18 67.00 Quite High
Neuroblastoma 9 44.68 Quite Low
INFLAMMATION 2 19.88 Low Low
Alzheimer's Dementia 54 9.16 Low Low
Toxicity 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tanemura et al. showed that tau was hyperphosphorylated in FAD-associated PS1 mutant (I213T) knock-in mice in the absence of A?
Phosphorylation (hyperphosphorylated) of FAD associated with targeted disruption and disease
1) Confidence 0.79 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.82 Pain Relevance 0.04
Interestingly, disruption of DTG motif in PS1-D257TA/D385TG, PS1-D257TG/D385TA or PS1-D385TA template did not cause reversion of the A?
Phosphorylation (template) of PS1
2) Confidence 0.66 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.16 Pain Relevance 0
Interestingly, disruption of DTG motif in PS1-D257TA/D385TG, PS1-D257TG/D385TA or PS1-D385TA template did not cause reversion of the A?
Phosphorylation (template) of PS1
3) Confidence 0.66 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.16 Pain Relevance 0
Interestingly, disruption of DTG motif in PS1-D257TA/D385TG, PS1-D257TG/D385TA or PS1-D385TA template did not cause reversion of the A?
Phosphorylation (template) of PS1-D257TG
4) Confidence 0.66 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.16 Pain Relevance 0
In vitro kinase assay showed that activated JNK directly phosphorylated presenilin 1, which is the core component of ?
Phosphorylation (phosphorylated) of presenilin 1
5) Confidence 0.05 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2427353 Disease Relevance 0.30 Pain Relevance 0.03

General Comments

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