INT193939

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 6.16
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PSEN1) Golgi apparatus (PSEN1) endoplasmic reticulum (PSEN1)
embryo development (PSEN1) peptidase activity (PSEN1) cell death (PSEN1)
Anatomy Link Frequency
fibroblasts 1
PSEN1 (Homo sapiens)
PSEN1 - D385T (1) PSEN1 - A246E (1)
Pain Link Frequency Relevance Heat
cINOD 36 100.00 Very High Very High Very High
bradykinin 150 99.66 Very High Very High Very High
nud 10 99.48 Very High Very High Very High
Inflammation 71 99.06 Very High Very High Very High
Pain score 20 98.88 Very High Very High Very High
Pain scale 22 98.40 Very High Very High Very High
Dismenorea 76 82.88 Quite High
Pain 144 76.80 Quite High
Hippocampus 27 67.96 Quite High
cytokine 11 65.28 Quite High
Disease Link Frequency Relevance Heat
Disease 628 100.00 Very High Very High Very High
INFLAMMATION 77 99.98 Very High Very High Very High
Dyspepsia 10 99.48 Very High Very High Very High
Pain 172 98.60 Very High Very High Very High
Blister 4 96.64 Very High Very High Very High
Targeted Disruption 187 95.12 Very High Very High Very High
Reprotox - General 1 12 94.32 High High
Alzheimer's Dementia 191 93.08 High High
Retinoblastoma 2 92.72 High High
Cancer 4 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, complementation of FAD-associated variants of PS2 selectively elevated A?
FAD Binding (complementation) of associated with disease
1) Confidence 0.36 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.91 Pain Relevance 0
Coexpression of Cox2, an enzyme implicated in inflammation and inhibited by a class of anti-inflammatory drugs, with APPswe and PS1A246E did not modify A?
PS1 Binding (drugs) of associated with inflammation and cinod
2) Confidence 0.36 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 1.57 Pain Relevance 0.53
-secretase, a multimeric complex whose proteolytic activity is regulated by binding of PS1/2 at its catalitic site.
PS1 Binding (binding) of
3) Confidence 0.35 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.45 Pain Relevance 0.06
This compares with PS-1 A246E and L286V mutations whose age of AD onset is generally later than 40 and whose fibroblasts secrete 2-3-fold more A?
PS-1 A246E (A246E) Binding (compares) of in fibroblasts associated with disease
4) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.45 Pain Relevance 0
No matter which stimulation/inhibition mechanism is operative, our PS1-D385TG mutant distinguishes itself from wild type and other mutants in that this mutation has changed the enzyme structure sufficiently to have a significant effect in its ability to recognize and cleave substrates and be inhibited.
PS1-D385TG Binding (recognize) of
5) Confidence 0.30 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.09 Pain Relevance 0
The presenilin and signal peptidase consensus motif GxGD has been studied with regard to its role in the context of the ?
presenilin Binding (studied) of
6) Confidence 0.30 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0 Pain Relevance 0
Indeed, our preliminary experiments based on a reporter-depending assay suggested that both PS1-D385TG and PS1-D257TG/D385T also reduced processing at the APP ?
PS1-D257TG (D385T) Binding (/) of
7) Confidence 0.30 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0 Pain Relevance 0
We, therefore, propose a possible model in which PS1-D385TG adopts a conformation, within the ?
PS1-D385TG Binding (conformation) of
8) Confidence 0.30 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0 Pain Relevance 0
Thus the decreased responsiveness of ERK activation by 250 nM BK is specifically associated with PS-1 mutant AD.
PS-1 Binding (associated) of associated with disease and bradykinin
9) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.23 Pain Relevance 0.38
Gastric reflux occurred more often with FAD but had no association with the treatment length of three or four cycles.
FAD Neg (no) Binding (association) of associated with nud
10) Confidence 0.16 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1940310 Disease Relevance 0.62 Pain Relevance 0.49
Reactions associated with FAD noted by traditional Chinese medicine physicians were inner heat reaction, such as blisters and pimples, and disturbed menstruation, such as amenorrhea and menorrhagia.
FAD Binding (associated) of associated with blister and reprotox - general 1
11) Confidence 0.14 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1940310 Disease Relevance 0.84 Pain Relevance 0.48

General Comments

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