INT193945

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.28
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) plasma membrane (Notch1)
nucleus (Notch1) embryo development (Notch1) cytoplasm (Notch1)
Anatomy Link Frequency
Notch 5
wing disc 1
T cell 1
Notch1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 14 90.68 High High
Inflammatory mediators 2 84.44 Quite High
cytokine 26 73.52 Quite High
glial activation 2 50.36 Quite High
sodium channel 3 26.96 Quite Low
ischemia 9 19.64 Low Low
Inflammation 44 5.00 Very Low Very Low Very Low
cINOD 38 5.00 Very Low Very Low Very Low
Eae 10 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 62 90.28 High High
Targeted Disruption 38 87.16 High High
Recurrence 3 85.44 High High
Neurodegenerative Disease 7 82.56 Quite High
Injury 40 71.72 Quite High
Disease 200 70.56 Quite High
Death 13 69.32 Quite High
Leukemia 4 52.00 Quite High
Coronary Heart Disease 3 46.08 Quite Low
Brain Disease 4 45.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two families of transmembrane ligands interact with the Notch receptors, the Delta and the Jagged/Serrate proteins.
Notch Binding (interact) of in Notch
1) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.05 Pain Relevance 0
Interactions between Notch and Wnt signaling were first uncovered in the developing wing disc of the fly (for review see [78]).
Notch Binding (Interactions) of in wing disc
2) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.07 Pain Relevance 0
In vertebrates, mutually dependent interactions between Notch and Wnt signaling have been described in several processes like somitogenesis or T-cell development [26], [78].
Notch Binding (interactions) of in Notch
3) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.09 Pain Relevance 0
Other growth factors, including Notch, FGF and BMP family members and their corresponding receptors, as well as the cell surface glycoprotein CD44 were also increased on the SuperArray, however, changes in their expression levels remain to be validated (Table S1).


Notch Binding (receptors) of in Notch
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832687 Disease Relevance 0.07 Pain Relevance 0.04
Notch signaling regulates CD4/CD8 T cell lineage commitment, whereas PS/?
Notch Binding (signaling) of in T cell
5) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.86 Pain Relevance 0.15
An independent C. elegans genetic screen identified aph-1 and pen-2 as enhancers of sel-12/Presenilin function, and showed that aph-2, aph-1 and pen-2 are required for Notch signaling, PS1 accumulation, and ?
Notch Binding (signaling) of in Notch
6) Confidence 0.02 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.06 Pain Relevance 0
One study showed that the ectodomain of Nicastrin binds to APP and Notch and can recruit them into the ?
Notch Binding (binds) of in Notch
7) Confidence 0.02 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.07 Pain Relevance 0

General Comments

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