INT193954

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.88
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (App, Psen1) cell adhesion (App, Psen1) plasma membrane (App, Psen1)
mitochondrion (Psen1) endoplasmic reticulum (Psen1) intracellular (Psen1)
Anatomy Link Frequency
Notch 1
App (Mus musculus)
Psen1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 1 66.64 Quite High
Hippocampus 3 57.20 Quite High
Kinase C 6 5.00 Very Low Very Low Very Low
sodium channel 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
long-term potentiation 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 23 99.96 Very High Very High Very High
Adhesions 8 88.68 High High
Herpes Simplex Virus 1 82.48 Quite High
Disease 139 81.40 Quite High
Aging 19 62.40 Quite High
Cognitive Disorder 10 58.80 Quite High
Syndrome 5 57.92 Quite High
Death 4 34.04 Quite Low
Alzheimer's Dementia 13 5.00 Very Low Very Low Very Low
Apoptosis 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, APP and Notch can interact with PS1 in the presence of active site ?
APP Binding (interact) of PS1 in Notch
1) Confidence 0.38 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0 Pain Relevance 0
Male APP/PS1 transgenic mice and their wild-type littermates were randomly assigned to different diet groups.
APP Binding (/) of PS1 associated with targeted disruption
2) Confidence 0.34 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.58 Pain Relevance 0.03
However, another study failed to verify the interaction between APP and kinesin-I and the co-transport of BACE1 and PS1 with APP [28].
APP Binding (interaction) of PS1
3) Confidence 0.22 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.30 Pain Relevance 0.03

General Comments

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