INT19396

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Context Info
Confidence 0.53
First Reported 1980
Last Reported 2010
Negated 3
Speculated 11
Reported most in Abstract
Documents 66
Total Number 80
Disease Relevance 37.41
Pain Relevance 30.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1)
cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)
Anatomy Link Frequency
muscle 4
bladder 2
neck 2
upper 2
skeletal muscle 1
Rac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 241 100.00 Very High Very High Very High
Botox 154 100.00 Very High Very High Very High
Myofascial pain syndrome 21 100.00 Very High Very High Very High
Analgesic 7 100.00 Very High Very High Very High
qutenza 6 100.00 Very High Very High Very High
cINOD 3 100.00 Very High Very High Very High
lidocaine 2 100.00 Very High Very High Very High
Piles 2 100.00 Very High Very High Very High
backache 4 99.84 Very High Very High Very High
Migraine 34 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 125 100.00 Very High Very High Very High
Dystonia 28 100.00 Very High Very High Very High
INFLAMMATION 11 100.00 Very High Very High Very High
Temporomandibular Joint Disorders 2 100.00 Very High Very High Very High
Syndrome 53 99.98 Very High Very High Very High
Cervical Cancer 23 99.84 Very High Very High Very High
Overactive Bladder 15 99.84 Very High Very High Very High
Tension-type Headache 12 99.84 Very High Very High Very High
Low Back Pain 5 99.84 Very High Very High Very High
Headache 193 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Influence of botulinum toxin on myogenous facial pain].
Regulation (Influence) of botulinum toxin associated with pain and headache
1) Confidence 0.53 Published 2005 Journal Schmerz Section Title Doc Link 15712004 Disease Relevance 0.20 Pain Relevance 0.20
Cystometry revealed that cyclophosphamide and botulinum toxin A treatments altered non-voiding (i.e. cyclophosphamide increased, botulinum toxin A decreased) but not voiding contraction frequency suggesting that alterations in urothelial ATP release selectively diminished underlying bladder C-fiber nerve activity.
Regulation (altered) of botulinum toxin in bladder associated with c fibre and overactive bladder
2) Confidence 0.45 Published 2005 Journal Neurochem. Int. Section Abstract Doc Link 15970360 Disease Relevance 0.63 Pain Relevance 0.18
OBJECTIVE: To compare the effects of botulinum toxin type A with those of amitriptyline on the treatment of chronic daily migraines.
Regulation (effects) of botulinum toxin associated with migraine disorders, endep and botox
3) Confidence 0.40 Published 2010 Journal Clin Neurol Neurosurg Section Abstract Doc Link 20399553 Disease Relevance 0.17 Pain Relevance 0.25
OBJECTIVE: To evaluate the effects of botulinum toxin type Afor the treatment of provoked vestibulodynia.
Regulation (effects) of botulinum toxin associated with vulvodynia
4) Confidence 0.39 Published 2006 Journal J Reprod Med Section Abstract Doc Link 16846084 Disease Relevance 0.17 Pain Relevance 0.04
Botulinum toxin is a safe, effective and relatively simple treatment for spasmodic torticollis.
Regulation (effective) of Botulinum toxin associated with torticollis
5) Confidence 0.39 Published 1991 Journal Mov. Disord. Section Abstract Doc Link 2057005 Disease Relevance 0.60 Pain Relevance 0.18
METHODS: This is a case report of a patient with a 20-year history of palmar hyperhidrosis who had previously tried several unsuccessful techniques to control pain during botulinum toxin injections to his palms.
Regulation (control) of botulinum toxin
6) Confidence 0.39 Published 2003 Journal Dermatol Surg Section Body Doc Link 12974705 Disease Relevance 0.17 Pain Relevance 0
Additional study is under way to determine the effectiveness of botulinum toxin for the treatment of chronic cluster headaches.
Spec (determine) Regulation (effectiveness) of botulinum toxin associated with cluster headache and headache
7) Confidence 0.39 Published 2002 Journal Clin J Pain Section Abstract Doc Link 12569965 Disease Relevance 1.68 Pain Relevance 1.79
BACKGROUND: Botulinum toxin injections are effective in the treatment of palmar and plantar hyperhidrosis, but discomfort has limited its use.
Regulation (effective) of Botulinum toxin associated with skin appendage disease
8) Confidence 0.39 Published 2009 Journal J Cutan Med Surg Section Abstract Doc Link 19769833 Disease Relevance 0.10 Pain Relevance 0
To examine the effects of botulinum toxin injection application for the treatment of upper airway obstruction due to hyperactive lateral pterygoid muscle contraction, we applied botulinum toxin injection.
Spec (examine) Regulation (effects) of botulinum toxin in upper associated with airway obstruction
9) Confidence 0.39 Published 2006 Journal Cranio Section Abstract Doc Link 16933464 Disease Relevance 0.67 Pain Relevance 0.10
The effects of botulinum toxin have been demonstrated in pain syndromes such as migraine, tension headache, and postherpetic neuralgia.
Regulation (effects) of botulinum toxin associated with pain, syndrome, migraine, headache and postherpetic neuralgia
10) Confidence 0.39 Published 2005 Journal Clin Neuropharmacol Section Abstract Doc Link 16062093 Disease Relevance 0.78 Pain Relevance 0.68
CONCLUSIONS: A single intrasphincter injection of botulinum toxin was more effective and safer than repeated applications of glyceryl trinitrate in reducing early postoperative pain at rest but not during defecation.


Regulation (effective) of botulinum toxin
11) Confidence 0.38 Published 2006 Journal Dis. Colon Rectum Section Body Doc Link 16990976 Disease Relevance 0 Pain Relevance 0
Botulinum toxin vs. topical glyceryl trinitrate ointment for pain control in patients undergoing hemorrhoidectomy: a randomized trial.
Regulation (control) of Botulinum toxin associated with pain and piles
12) Confidence 0.38 Published 2006 Journal Dis. Colon Rectum Section Title Doc Link 16990976 Disease Relevance 0.19 Pain Relevance 0.32
Botulinum toxin injections are effective in some tremor patterns, especially wrist flexion/extension and head tremor.
Regulation (effective) of Botulinum toxin in head associated with tremor
13) Confidence 0.37 Published 2006 Journal Curr Treat Options Neurol Section Abstract Doc Link 16569384 Disease Relevance 0.62 Pain Relevance 0.23
The patients received either botulinum toxin A or physiological saline injections on 2 occasions 4 weeks apart.
Regulation (received) of botulinum toxin
14) Confidence 0.37 Published 2006 Journal Clin J Pain Section Body Doc Link 16340597 Disease Relevance 0 Pain Relevance 0
The aim of this work was to determine the effect of small doses (5 U) of botulinum toxin A (BTA) injected directly into the painful trigger points of the muscles, using a double-blind crossover technique.
Regulation (effect) of botulinum toxin in muscles associated with pain
15) Confidence 0.37 Published 2006 Journal Clin J Pain Section Abstract Doc Link 16340597 Disease Relevance 0.44 Pain Relevance 0.44
Baclofen, tizanidine and botulinum toxin A, agents used to treat disorders of muscle tone, have been studied as potential preventative treatments for migraine, tension-type headache and other related disorders.
Regulation (treatments) of botulinum toxin in muscle associated with migraine and headache
16) Confidence 0.37 Published 2003 Journal CNS Drugs Section Abstract Doc Link 12696998 Disease Relevance 0.62 Pain Relevance 0.62
Techniques reviewed include the use of botulinum toxin injections in the treatment of myofascial pain, cervical zygapophyseal joint injections and radiofrequency neuroablation in the treatment of posterior column disorders, and epidural steroid injections in the treatment of cervical radicular and referred upper-limb pain.
Regulation (use) of botulinum toxin in upper associated with pain, neuroablation, snapping jaw and epidural
17) Confidence 0.37 Published 2007 Journal Arch Phys Med Rehabil Section Abstract Doc Link 17321843 Disease Relevance 0.55 Pain Relevance 0.82
Role for botulinum toxin in back pain treatment in adults with cerebral palsy: report of a case.
Regulation (Role) of botulinum toxin associated with cerebral palsy and backache
18) Confidence 0.37 Published 2004 Journal Joint Bone Spine Section Title Doc Link 14769528 Disease Relevance 0.20 Pain Relevance 0.19
Focal spasticity therapy with botulinum toxin: effects on function, activities of daily living and pain in 100 adult patients.
Regulation (effects) of botulinum toxin associated with pain and spasticity
19) Confidence 0.36 Published 2006 Journal J Rehabil Med Section Title Doc Link 16702083 Disease Relevance 0.20 Pain Relevance 0.40
The role of nerve blocks and botulinum toxin injections in the management of cluster headaches.
Regulation (role) of botulinum toxin in nerve associated with cluster headache and headache
20) Confidence 0.36 Published 2009 Journal Curr Pain Headache Rep Section Title Doc Link 19272284 Disease Relevance 0.66 Pain Relevance 0.87

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