INT193964

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Context Info
Confidence 0.00
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.74
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Mapk1, Gsk3b) protein complex (Mapk1, Gsk3b) cytoplasm (Mapk1, Gsk3b)
cytosol (Mapk1, Gsk3b) kinase activity (Mapk1, Gsk3b) cell differentiation (Gsk3b)
Mapk1 (Mus musculus)
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 1 99.44 Very High Very High Very High
cINOD 2 8.20 Low Low
sodium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 63 98.44 Very High Very High Very High
Targeted Disruption 11 94.80 High High
INFLAMMATION 1 7.96 Low Low
Alzheimer's Dementia 6 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Adhesions 5 5.00 Very Low Very Low Very Low
Frontotemporal Dementia 5 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low
Disease Progression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Part of the underlying mechanisms might be that PS modulates PI3K/Akt and ERK signaling pathways to downregulate GSK-3 activity and tau phosphorylation; and FAD mutations inhibit these pathways in a way similar to that by PS1 deficiency [91,92].
ERK Negative_regulation (downregulate) of GSK-3 associated with eae and disease
1) Confidence 0.00 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.74 Pain Relevance 0.05

General Comments

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