INT193970

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.06
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PSEN1, Psen2) endoplasmic reticulum (PSEN1, Psen2) embryo development (PSEN1, Psen2)
peptidase activity (PSEN1, Psen2) nucleus (PSEN1, Psen2) locomotion (PSEN1, Psen2)
Anatomy Link Frequency
Notch 1
PSEN1 (Homo sapiens)
Psen2 (Mus musculus)
Pain Link Frequency Relevance Heat
NSAID 6 52.24 Quite High
Sodium channel 3 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 189 100.00 Very High Very High Very High
Targeted Disruption 33 86.36 High High
Disease Progression 3 71.36 Quite High
Alzheimer's Dementia 18 5.00 Very Low Very Low Very Low
Apoptosis 15 5.00 Very Low Very Low Very Low
Adhesions 15 5.00 Very Low Very Low Very Low
Frontotemporal Dementia 15 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 3 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most of the aggressive forms of FAD cases (less than 30 years of age at onset) are associated with PS1 rather than PS2.
FAD Binding (associated) of PS2 associated with disease
1) Confidence 0.36 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.88 Pain Relevance 0.05
But interestingly, FAD-associated variant PS2N141I is able to rescue Notch-associated developmental defects compared to PS2 wt in the absence of PS1, which makes the precise functions of different PS/?
FAD Binding (associated) of PS2 in Notch associated with disease
2) Confidence 0.36 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.85 Pain Relevance 0
Differential functions of wild type and FAD-associated PS1 and PS2
FAD Binding (associated) of PS2 associated with disease
3) Confidence 0.32 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.33 Pain Relevance 0

General Comments

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