INT19399

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Context Info
Confidence 0.36
First Reported 1981
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 43
Total Number 45
Disease Relevance 33.39
Pain Relevance 13.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
blood 2
lymphocyte 2
plasma cells 1
erythrocyte 1
Rf (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 940 100.00 Very High Very High Very High
Inflammation 263 99.92 Very High Very High Very High
cINOD 25 99.72 Very High Very High Very High
Pain 66 99.58 Very High Very High Very High
Snapping jaw 4 99.58 Very High Very High Very High
Osteoarthritis 160 99.32 Very High Very High Very High
Arthritis 173 99.22 Very High Very High Very High
spinal inflammation 20 98.76 Very High Very High Very High
Etanercept 15 98.56 Very High Very High Very High
cytokine 154 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 951 100.00 Very High Very High Very High
INFLAMMATION 230 99.92 Very High Very High Very High
Disease 268 99.88 Very High Very High Very High
Lyme Disease 12 99.80 Very High Very High Very High
Anaemia 2 99.62 Very High Very High Very High
Conjunctivitis 2 99.60 Very High Very High Very High
Pain 47 99.58 Very High Very High Very High
Temporomandibular Joint Syndrome 4 99.58 Very High Very High Very High
Hypergammaglobulinemia 2 99.58 Very High Very High Very High
Hepatitis 6 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We noticed a prologation of acoustic reflex latency in five patients (10 per cent) which was found to be correlated with the temporomandibular joint involvement and the presence of rheumatoid factor (RF).
Gene_expression (presence) of RF in temporomandibular joint associated with snapping jaw
1) Confidence 0.36 Published 1995 Journal J Laryngol Otol Section Abstract Doc Link 7561491 Disease Relevance 0.99 Pain Relevance 0.35
RF was positive in two patients, one of them had rheumatoid arthritis and FANA was positive in six (9%) patients; all of them had hypothyroidism.
Gene_expression (positive) of RF associated with thyroid disease and rheumatoid arthritis
2) Confidence 0.32 Published 2007 Journal Rheumatol. Int. Section Abstract Doc Link 17102943 Disease Relevance 2.56 Pain Relevance 0.45
An enzyme-linked immunosorbent assay (ELISA) for the quantitative detection of rheumatoid factors (RF) was developed using mouse monoclonal antibodies against human IgG, IgA and IgM together with the biotin/streptavidin enhancement system.
Gene_expression (detection) of RF
3) Confidence 0.28 Published 1989 Journal Br. J. Rheumatol. Section Abstract Doc Link 2472849 Disease Relevance 0.58 Pain Relevance 0.22
Compared to agglutination assays, the ELISA for the quantitative detection of RF isotypes is a more reproducible and sensitive test which avoids some of the problems encountered in earlier ELISA methods.
Gene_expression (detection) of RF
4) Confidence 0.28 Published 1989 Journal Br. J. Rheumatol. Section Abstract Doc Link 2472849 Disease Relevance 0.61 Pain Relevance 0.21
Current smoking was a predictor for five mental health indicators: RF poor mental health (1.5), RF sad/blue/depressed (1.8), RF worried/tense/anxious (1.7), RF lack of rest/sleep (1.4) and MDE (1.9) but not for RF lack of energy nor for any of the poor physical health indicators.
Neg (lack) Gene_expression (lack) of RF associated with mental disorders, nicotine addiction and fatigue
5) Confidence 0.16 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1431510 Disease Relevance 1.17 Pain Relevance 0.09
Current smoking was a predictor for five mental health indicators: RF poor mental health (1.5), RF sad/blue/depressed (1.8), RF worried/tense/anxious (1.7), RF lack of rest/sleep (1.4) and MDE (1.9) but not for RF lack of energy nor for any of the poor physical health indicators.
Gene_expression (worried) of RF associated with mental disorders, nicotine addiction and fatigue
6) Confidence 0.16 Published 2006 Journal Health Qual Life Outcomes Section Body Doc Link PMC1431510 Disease Relevance 1.17 Pain Relevance 0.09
The synovial environment in early RA may modulate fibroblast function, leading to the production of factors facilitating lymphoid aggregate formation and allowing local RF production.
Gene_expression (production) of RF in fibroblast associated with rheumatoid arthritis
7) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175027 Disease Relevance 1.05 Pain Relevance 0.57
Serum levels of IgM-rheumatoid factor (RF) decreased significantly at 24 weeks and anti-citrullinated peptide antibody (ACPA) levels at 36 weeks.
Gene_expression (levels) of RF
8) Confidence 0.13 Published 2008 Journal Annals of the Rheumatic Diseases Section Abstract Doc Link PMC2564787 Disease Relevance 0.33 Pain Relevance 0.16
The IgM-RF and ACPA levels were not available for the week 24 visit and week 36 for the patient who withdrew from the study after 20 weeks because of insufficient clinical response.
Gene_expression (levels) of RF
9) Confidence 0.13 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564787 Disease Relevance 0 Pain Relevance 0.04
Decreased IgM-RF and ACPA levels after rituximab treatment
Gene_expression (levels) of RF
10) Confidence 0.13 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564787 Disease Relevance 0 Pain Relevance 0.04
There was a highly significant decrease in serum levels of IgM-RF at 16 (p?
Gene_expression (was) of RF
11) Confidence 0.13 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564787 Disease Relevance 0 Pain Relevance 0.03
First, B cells may drive synovial inflammation by production of autoantibodies;20 they are the precursors of short-lived plasma cells associated with production of autoantibodies, such as IgM-RF and ACPA.
Gene_expression (production) of RF in plasma cells associated with inflammation
12) Confidence 0.13 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564787 Disease Relevance 0.62 Pain Relevance 0.39
Correlations between changes in synovial cell populations, serum IgM-RF and ACPA levels and the DAS28 between baseline, 4 weeks and 16 weeks after treatment were determined by Spearman correlation coefficient.
Gene_expression (levels) of RF in synovial cell
13) Confidence 0.13 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564787 Disease Relevance 0 Pain Relevance 0
Thus, serial IgM-RF and ACPA levels were available for 22 patients.
Gene_expression (levels) of RF
14) Confidence 0.13 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564787 Disease Relevance 0 Pain Relevance 0.03
Seven of the eight patients whose disease developed into RA already expressed RF and anti-CCP antibody at this early stage, within weeks of symptom onset.
Gene_expression (expressed) of RF associated with rheumatoid arthritis and disease
15) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175027 Disease Relevance 1.56 Pain Relevance 0.52
Serum levels of IgM-rheumatoid factor (RF) and ACPA (anti-CCP2 ELISA, Immunoscan RA, Mark 2, Euro Diagnostica, Arnhem, the Netherlands) were determined at baseline and weeks 4, 16, 24 and 36 after treatment.
Spec (determined) Gene_expression (levels) of RF associated with rheumatoid arthritis
16) Confidence 0.12 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564787 Disease Relevance 0.52 Pain Relevance 0.59
Changes in peripheral blood lymphocytes, synovial cell populations, as well as serum levels of total IgM, total IgG, IgM-RF and ACPA were compared using Wilcoxon signed rank test for paired data.
Gene_expression (levels) of RF in blood
17) Confidence 0.12 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564787 Disease Relevance 0.06 Pain Relevance 0
Yet they may decrease the production of the rheumatoid factor (RF).
Gene_expression (production) of RF
18) Confidence 0.09 Published 1991 Journal Rev Rhum Mal Osteoartic Section Abstract Doc Link 2057729 Disease Relevance 0.42 Pain Relevance 0.63
In cross-sectional feasibility studies, both RF and anti-CCP were easily detected in the majority of the RA synovial extracts.
Gene_expression (detected) of RF associated with rheumatoid arthritis
19) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.41 Pain Relevance 0.14
These patients were rheumatoid factor (RF) and HLA-B27 negative.
Neg (negative) Gene_expression (negative) of RF
20) Confidence 0.07 Published 1997 Journal Semin. Arthritis Rheum. Section Abstract Doc Link 9355205 Disease Relevance 1.49 Pain Relevance 0.35

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