INT194018

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.59
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Camk2a) kinase activity (Camk2a) cytoplasm (Camk2a)
Camk2a (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 8 100.00 Very High Very High Very High
Lasting pain 9 98.44 Very High Very High Very High
Anterior cingulate cortex 34 83.32 Quite High
Pain 19 73.92 Quite High
Glutamate 73 50.00 Quite Low
allodynia 15 50.00 Quite Low
depression 14 50.00 Quite Low
Inflammation 7 45.92 Quite Low
amygdala 5 26.24 Quite Low
Hippocampus 20 25.28 Quite Low
Disease Link Frequency Relevance Heat
Pain 27 98.00 Very High Very High Very High
Cognitive Disorder 6 96.56 Very High Very High Very High
Targeted Disruption 116 94.80 High High
Injury 24 88.16 High High
Nociception 15 86.96 High High
Attention Deficit Hyperactivity Disorder 2 83.32 Quite High
Schizophrenia 18 68.08 Quite High
Anxiety Disorder 4 65.68 Quite High
Hallucination 4 61.68 Quite High
Neuropathic Pain 25 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present results provide strong evidence that enhancing the activity of NMDA receptors or CaMKII does not have the same consequence on persistent pain despite being equally implicated in learning-related synaptic plasticity and behavioral memory.
Positive_regulation (enhancing) of CaMKII Binding (activity) of associated with pain, lasting pain and nmda receptor
1) Confidence 0.50 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 1.17 Pain Relevance 0.30
The Vglut2flox/flox;CamKII-Cre mice showed increased dominance but also increased interaction with their counterparts.
Positive_regulation (increased) of CamKII-Cre Binding (interaction) of
2) Confidence 0.09 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.71 Pain Relevance 0
The Vglut2flox/flox;CamKII-Cre mice showed increased dominance but also increased interaction with their counterparts.
Positive_regulation (increased) of CamKII-Cre Binding (interaction) of
3) Confidence 0.09 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853350 Disease Relevance 0.71 Pain Relevance 0

General Comments

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