INT194019

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.18
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
digit 1
skin 1
Acc (Mus musculus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 108 100.00 Very High Very High Very High
depression 14 99.64 Very High Very High Very High
nMDA receptor 8 96.16 Very High Very High Very High
Pain 25 95.92 Very High Very High Very High
long-term potentiation 10 91.20 High High
allodynia 29 81.28 Quite High
Pyramidal cell 2 81.12 Quite High
tolerance 6 69.68 Quite High
phantom pain 6 66.28 Quite High
Lasting pain 43 60.72 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 61 100.00 Very High Very High Very High
Depression 14 99.64 Very High Very High Very High
Injury 35 98.96 Very High Very High Very High
Amputation 39 97.76 Very High Very High Very High
Pain 73 95.92 Very High Very High Very High
Nervous System Injury 10 93.28 High High
Neuropathic Pain 31 81.28 Quite High
Nociception 9 71.32 Quite High
Impaired Glucose Tolerance 10 69.68 Quite High
Inflammatory Pain 6 59.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Why was behavioral sensitization to injury reduced while synaptic depression abolished in the ACC CaMKII transgenic mice?
Gene_expression (transgenic mice) of ACC associated with targeted disruption, depression, injury and anterior cingulate cortex
1) Confidence 0.65 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 1.26 Pain Relevance 0.87
As shown in Fig. 1B, we found that larger number of the layer II pyramidal-like neurons in the ACC expressed P-Erk immunoreactivity at two weeks after single digit amputation.
Gene_expression (expressed) of ACC in digit associated with amputation and anterior cingulate cortex
2) Confidence 0.65 Published 2008 Journal Mol Pain Section Body Doc Link PMC2503974 Disease Relevance 1.27 Pain Relevance 1.03
To explore if the AMPK signaling cascade was involved in ADH and/or ethanol-induced cardiac contractile response, AMPK, its downstream signaling molecule ACC and the AMPK activating signal LKB1 were examined.
Gene_expression (explore) of ACC
3) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.07 Pain Relevance 0.03
The enhanced expression of P-Erk in ACC neurons and their dendrites after brushing normal skin of amputated hindpaw suggests that Erk activity are recruited at distal synapses in ACC neurons.
Gene_expression (expression) of ACC in skin associated with anterior cingulate cortex
4) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2503974 Disease Relevance 0.58 Pain Relevance 0.62

General Comments

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