INT194020

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.29
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Camk2a) kinase activity (Camk2a) cytoplasm (Camk2a)
Anatomy Link Frequency
forebrain 2
Camk2a (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 8 99.12 Very High Very High Very High
Anterior cingulate cortex 34 92.40 High High
withdrawal 10 91.64 High High
depression 30 83.92 Quite High
Inflammation 7 78.96 Quite High
tail-flick 3 66.80 Quite High
interneuron 2 59.12 Quite High
allodynia 9 50.00 Quite Low
Neuronal excitability 1 43.16 Quite Low
long-term potentiation 8 37.44 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 56 93.36 High High
Injury 14 90.08 High High
Depression 30 83.92 Quite High
Adhesions 4 82.92 Quite High
INFLAMMATION 7 78.96 Quite High
Nociception 7 53.76 Quite High
Neuropathic Pain 9 50.00 Quite Low
Pain 15 36.48 Quite Low
Hyperalgesia 7 5.00 Very Low Very Low Very Low
Inflammatory Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results consistently demonstrate that behavioral responses to acute noxious thermal and mechanical stimuli were not affected by enhanced forebrain CaMKII activity.
Neg (not) Regulation (affected) of Positive_regulation (enhanced) of CaMKII in forebrain
1) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1513196 Disease Relevance 0.93 Pain Relevance 0.39
On the other hand, shortening the duration of coupled conditioning stimulation consisting of GABABR activation and the [Ca2+]i increase dramatically weakened the suppressive effect of GABABR activation on the CaMKII activation (Figure 3B–E; also see Supplementary Figure 3).
Regulation (effect) of Positive_regulation (activation) of CaMKII
2) Confidence 0.44 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
On the other hand, the suppression of sustained CaMKII activation largely depended on the duration of GABABR activation.
Regulation (depended) of Positive_regulation (activation) of CaMKII
3) Confidence 0.26 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.35 Pain Relevance 0.13

General Comments

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