INT194031

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.07
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SQSTM1) cytosol (SQSTM1) nucleoplasm (SQSTM1)
nucleus (SQSTM1) response to stress (SQSTM1) cytoplasm (SQSTM1)
SQSTM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 5 94.28 High High
Pain 6 93.64 High High
Glutamate 3 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 74 99.50 Very High Very High Very High
Spontaneous Fractures 4 95.36 Very High Very High Very High
Osteoarthritis 5 94.28 High High
Pain 6 93.64 High High
Bone Disease 23 88.72 High High
Deafness 4 88.64 High High
Repression 3 86.76 High High
Stress 22 61.08 Quite High
Genetic Predisposition To Disease 1 60.24 Quite High
Iron Overload 1 58.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SQSTM1 was dispensable for the induction of the Keap1-Nrf2 pathway, as Nrf2 activation by tert-butylhydroquinone or iodoacetamide was not affected by RNAi depletion of SQSTM1.
Neg (not) Regulation (affected) of SQSTM1
1) Confidence 0.41 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0
SQSTM1 is an important component of a signaling pathway that regulates the activity of NF-?
Regulation (important) of SQSTM1
2) Confidence 0.41 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.58 Pain Relevance 0.14
In a very recent report (23), Komatsu and colleagues have demonstrated an interaction between Keap1 and SQSTM1 and have defined the motifs in Keap1 and SQSTM1 responsible for this interaction.
Regulation (responsible) of SQSTM1
3) Confidence 0.41 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.14 Pain Relevance 0
Genetic factors have long been recognised to play an important role in Paget's disease [3-6] and recent studies by our own group and others indicate that between 40–50% of instances of familial Paget's disease are caused by mutations affecting the ubiquitin-associated (UBA) domain of the SQSTM1 gene [7-11].
Regulation (affecting) of SQSTM1 associated with disease
4) Confidence 0.27 Published 2006 Journal BMC Health Serv Res Section Body Doc Link PMC1513223 Disease Relevance 1.35 Pain Relevance 0.13

General Comments

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