INT194049

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.48
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP) extracellular region (CRP)
CRP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory marker 17 99.56 Very High Very High Very High
Inflammation 91 92.24 High High
Inflammatory mediators 8 50.00 Quite Low
cytokine 97 32.60 Quite Low
Inflammatory response 14 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 4 100.00 Very High Very High Very High
Fever 159 99.28 Very High Very High Very High
INFLAMMATION 130 99.24 Very High Very High Very High
Flavivirus Infection 80 98.56 Very High Very High Very High
Syndrome 71 96.32 Very High Very High Very High
Hypertension 25 95.04 Very High Very High Very High
Obesity 30 94.32 High High
Diabetes Mellitus 33 93.96 High High
Dengue 104 89.40 High High
Infection 48 81.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
enhanced associations with CRP, IL-6, and WBCs.
Positive_regulation (enhanced) of CRP Binding (associations) of
1) Confidence 0.48 Published 2006 Journal Environ Health Perspect Section Abstract Doc Link PMC1513328 Disease Relevance 1.53 Pain Relevance 0.15
Serum concentrations of C-reactive protein (CRP) and serum amyloid A (SAA) were substantially elevated in patients with fever (Table 2 and Additional File 2, Figure S1) which is typical for the syndrome.
Positive_regulation (elevated) of CRP Binding (concentrations) of associated with syndrome, alzheimer's dementia and fever
2) Confidence 0.34 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 1.05 Pain Relevance 0.04
Serum concentrations of C-reactive protein (CRP) and serum amyloid A (SAA) were substantially elevated in patients with fever (Table 2 and Additional File 2, Figure S1) which is typical for the syndrome.
Positive_regulation (elevated) of C-reactive protein Binding (concentrations) of associated with syndrome, alzheimer's dementia and fever
3) Confidence 0.34 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2944328 Disease Relevance 1.05 Pain Relevance 0.04
The (C4b2b) C3 can be activated by several mechanisms including immune complexes, CRP, Specific ICAM-3 Grabbing Non-Integrin (SIGN-1), phosphatidyl serine, complex polysaccharides, and others.
Positive_regulation (activated) of CRP Binding (complexes) of
4) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.85 Pain Relevance 0

General Comments

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