INT194066

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Context Info
Confidence 0.34
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.28
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Omp) signal transduction (Omp) nucleus (Omp)
cytoplasm (Omp) signal transducer activity (Omp)
Anatomy Link Frequency
olfactory 2
nerve 1
VRNs 1
olfactory nerve 1
olfactory bulb 1
Omp (Mus musculus)
Pain Link Frequency Relevance Heat
lidocaine 6 82.28 Quite High
Inflammation 47 66.88 Quite High
medulla 18 17.84 Low Low
cytokine 20 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 65 100.00 Very High Very High Very High
Apoptosis 157 99.24 Very High Very High Very High
Infection 201 92.80 High High
Encephalopathy 225 92.40 High High
Toxicity 16 89.16 High High
INFLAMMATION 51 66.88 Quite High
Creutzfeldt Jakob Disease 42 66.60 Quite High
Loss Of Sense Of Smell 30 57.24 Quite High
Chronic Wasting Disease 9 41.52 Quite Low
Scrapie 69 33.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
activated caspase-3 (1:100, rabbit anti-caspase-3 antibody; Abcam, Inc., Cambridge, MA), olfactory marker protein (OMP; 1:4,000, goat anti-OMP
Gene_expression (1:100) of OMP in olfactory
1) Confidence 0.34 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1513335 Disease Relevance 0 Pain Relevance 0
OMP, a specific peptide found only in mature OSNs (Kream and Margolis 1984), was markedly reduced in the OE of SG-instilled mice compared with saline-instilled
Gene_expression (reduced) of OMP
2) Confidence 0.34 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1513335 Disease Relevance 0.53 Pain Relevance 0
atrophy of the OMP-positive olfactory nerve bundles located
Gene_expression (atrophy) of OMP in olfactory nerve associated with frailty
3) Confidence 0.34 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1513335 Disease Relevance 0.31 Pain Relevance 0.03
activated caspase-3 (1:100, rabbit anti-caspase-3 antibody; Abcam, Inc., Cambridge, MA), olfactory marker protein (OMP; 1:4,000, goat anti-OMP
Gene_expression (1:100) of anti-OMP in olfactory
4) Confidence 0.34 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1513335 Disease Relevance 0 Pain Relevance 0
LSCM revealed that PrPSc deposition occurred in the OMP-positive soma and apical dendrites of vomeronasal receptor neurons (VRNs), but less frequently to the proximal dendrites in VRNs (Figure 5D to 5F).
Gene_expression (soma) of OMP-positive in VRNs
5) Confidence 0.20 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2855443 Disease Relevance 0.34 Pain Relevance 0
Dual immunofluorescence for OMP and PrPSc revealed a widespread OMP distribution in both the OSE and the nerve bundles located in the subepithelial layer (Figure 4A and 4C).
Gene_expression (distribution) of OMP in nerve
6) Confidence 0.20 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2855443 Disease Relevance 0.19 Pain Relevance 0
This conclusion is supported in the current study in which there was widespread PrPSc deposition in glomeruli in the olfactory bulb including at both the OMP-positive ORN nerve terminals and OMP-negative regions that likely contain mitral and tufted cell processes.
Gene_expression (deposition) of OMP in olfactory bulb
7) Confidence 0.20 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2855443 Disease Relevance 0.86 Pain Relevance 0
-tubulin and OMP expression following intranasal agent administration
Gene_expression (expression) of OMP
8) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765727 Disease Relevance 0.06 Pain Relevance 0.08

General Comments

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