INT194074

Context Info Confidence 0.38 First Reported 2006 Last Reported 2007 Negated 3 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 2.93 Pain Relevance 1.87

hydrolase activity, acting on glycosyl bonds (NAGLU) lysosome (NAGLU)

NAGLU (Homo sapiens)

Pain Link Frequency Relevance Heat palliative 2 98.72 Inflammation 18 97.28 Restless leg syndrome 120 96.44 aspirin 22 92.80 Inflammatory marker 8 92.56 cINOD 10 78.48 Inflammatory response 12 45.88 Pain 8 5.00 Antihistamine 4 5.00 imagery 3 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 42 97.28 Increased Venous Pressure Under Development 124 96.44 Death 8 94.36 Congenital Anomalies 6 82.48 Obesity 2 80.40 Cleidocranial Dysplasia 5 78.88 Coronary Heart Disease 3 77.88 Disease 43 73.88 Airway Obstruction 6 68.32 Apnoea 3 67.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To obtain a symmetrical distribution, data on NAG and protein

Regulation (data) of NAG

1) Confidence 0.38 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1513341 Disease Relevance 0.14 Pain Relevance 0.08

As shown in Figure 2A, the cutoff concentrations of NAG and protein HC obtained by our hybrid

Regulation (concentrations) of NAG

2) Confidence 0.38 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1513341 Disease Relevance 0 Pain Relevance 0

Until recently, there has been no effective therapy for MPS II.

Neg (no) Regulation (effective) of MPS II

3) Confidence 0.28 Published 2007 Journal Eur J Pediatr Section Body Doc Link PMC2234442 Disease Relevance 1.05 Pain Relevance 0.10

There was no change in urinary NAG levels post-exercise (table 3).

Neg (no) Regulation (change) of NAG

4) Confidence 0.14 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 1.06 Pain Relevance 1.02

There was no change in urinary NAG.

Neg (no) Regulation (change) of NAG

5) Confidence 0.14 Published 2006 Journal Thromb J Section Abstract Doc Link PMC1540420 Disease Relevance 0.67 Pain Relevance 0.67

General Comments

This test has worked.